Synthesis and bioassay of beta-(1,4)-D-mannans as potential agents against Alzheimer's disease
文献类型：期刊论文
| 作者 | Jiang, Ru-wei; Du, Xiao-guang; Zhang, Xuan ; Wang, Xin; Hu, Ding-yu; Meng, Tao; Chen, Yue-lei; Geng, Mei-yu; Shen, Jing-kang
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2013-12 |
| 卷号 | 34期号:12页码:1585-1591 |
| 关键词 | Alzheimer's disease A beta peptide oligosaccharide beta-(1,4)-D-mannan oligomannurarate 971 alzhemed neuroprotection medicinal chemistry |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2013.104 |
| 文献子类 | Article |
| 英文摘要 | Aim: Oligomannurarate 971 derived from a marine plant has shown neuroprotective effects. In this study we synthesized a series of truncated derivatives of the oligosaccharide, and investigated the effect of these derivatives against A beta peptide toxicity in vitro. Methods: The sulfoxide method was applied to synthesize the derivatives. SH-SY5Y human neuroblastoma cells were treated with A beta(1-40) (2 mu mol/L), and the cell viability was detected using a CCK8 assay. Results: A series of beta-(1,4)-D-mannosyl oligosaccharide, ranging from the disaccharide to the hexasaccharide, were synthesized. Addition of 10 mu mol/L beta-(1,4)-D-mannobiose 6, beta-(1,4)-D-mannotriose 9 or beta-(1,4)-D-mannotetraose 12 in SH-SY5Y cells significantly attenuated A beta 1-40-induced toxicity. The efficacies were similar to those caused by 10 mu mol/L oligomannurarate 971 or alzhemed. Other oligosaccharides including oligomaltoses and oligocelluloses were less active. Conclusion: Synthetic homogeneous short chain beta-(1,4)-D-mannans shows neuroprotective effect against A beta peptide toxicity similar to that of heterogeneous oligomannurarate 971 and alzhemed. |
| WOS关键词 | DIRECT CHEMICAL-SYNTHESIS ; BETA-MANNOPYRANOSIDES ; SULFOXIDE METHOD ; POLYSACCHARIDE ; PROTEIN |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program," China[2012ZX09301001] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5003750 |
| WOS记录号 | WOS:000328268600013 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277353]  |
| 专题 | 药理学第一研究室 中国科学院上海药物研究所 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物化学研究室 |
| 通讯作者 | Geng, Mei-yu |
| 作者单位 | Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Ru-wei,Du, Xiao-guang,Zhang, Xuan,et al. Synthesis and bioassay of beta-(1,4)-D-mannans as potential agents against Alzheimer's disease[J]. ACTA PHARMACOLOGICA SINICA,2013,34(12):1585-1591. |
| APA | Jiang, Ru-wei.,Du, Xiao-guang.,Zhang, Xuan.,Wang, Xin.,Hu, Ding-yu.,...&Shen, Jing-kang.(2013).Synthesis and bioassay of beta-(1,4)-D-mannans as potential agents against Alzheimer's disease.ACTA PHARMACOLOGICA SINICA,34(12),1585-1591. |
| MLA | Jiang, Ru-wei,et al."Synthesis and bioassay of beta-(1,4)-D-mannans as potential agents against Alzheimer's disease".ACTA PHARMACOLOGICA SINICA 34.12(2013):1585-1591. |
入库方式： OAI收割
来源：上海药物研究所
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