Racemosins A and B, two novel bisindole alkaloids from the green alga Caulerpa racemosa
文献类型：期刊论文
| 作者 | Liu, Ding-Quan2; Mao, Shui-Chun1,2; Zhang, Hai-Yan3 ; Yu, Xiao-Qing2; Feng, Mei-Tang2; Wang, Bin2; Feng, Li-Hua2; Guo, Yue-Wei3
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2013-12 |
| 卷号 | 91页码:15-20 |
| 关键词 | Green alga Caulerpa racemosa Bisindole alkaloids Racemosins A and B Neuro-protective activity |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2013.08.014 |
| 文献子类 | Article |
| 英文摘要 | Racemosin A (1), a structurally unique bisindole alkaloid possessing the seco-indolo[3,2-a] carbazole skeleton with two uncommon indolinenone units both conjugated with a methyl propenoate moiety, and its unusual cyclized derivative, racemosin B (2), were isolated from the green alga Caulerpa racemosa, together with the most commonly encountered pigment in the genus Caulerpa, caulerpin (3). Their structures were elucidated by extensive spectroscopic analysis and by comparison with data for related known compounds. A plausible biosynthetic pathway of 1 and 2 was proposed. In a neuro-protective assay, compound 1 significantly attenuated the A beta(25-35)-induced SH-SY5Y cell damage with a 14.6% increase in cell viability at the concentration of 10 mu M when compared to epigallocatechin gallate (EGCG, 16.57% increase at 10 mu M) as the positive control. (C) 2013 Elsevier B.V. All rights reserved. |
| WOS关键词 | WATER MARINE SPONGE ; HAMACANTHIN CLASSES ; INDOLE ALKALOIDS ; ANTIFUNGAL ; SPONGOSORITES ; DRAGMACIDIN ; TOPSENTIN ; CELLS |
| 资助项目 | National Natural Science Foundation of China[20862013] ; National Natural Science Foundation of China[81001397] ; National Natural Science Foundation of China[21162016] ; National Natural Science Foundation of China[81273430] ; National Marine "863" Project[SS2013AA090202] ; Natural Science Foundation of Jiangxi Province, China[2010GQY0217] ; Natural Science Foundation of Jiangxi Province, China[20114BAB205034] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000327574300003 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277354]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第二研究室 |
| 通讯作者 | Mao, Shui-Chun |
| 作者单位 | 1.Nanchang Univ, Inst Translat Med, Nanchang 330031, Peoples R China; 2.Nanchang Univ, Sch Pharm, Nanchang 330006, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ding-Quan,Mao, Shui-Chun,Zhang, Hai-Yan,et al. Racemosins A and B, two novel bisindole alkaloids from the green alga Caulerpa racemosa[J]. FITOTERAPIA,2013,91:15-20. |
| APA | Liu, Ding-Quan.,Mao, Shui-Chun.,Zhang, Hai-Yan.,Yu, Xiao-Qing.,Feng, Mei-Tang.,...&Guo, Yue-Wei.(2013).Racemosins A and B, two novel bisindole alkaloids from the green alga Caulerpa racemosa.FITOTERAPIA,91,15-20. |
| MLA | Liu, Ding-Quan,et al."Racemosins A and B, two novel bisindole alkaloids from the green alga Caulerpa racemosa".FITOTERAPIA 91(2013):15-20. |
入库方式： OAI收割
来源：上海药物研究所
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