From Formamide to Adenine: A Self-Catalytic Mechanism for an Abiotic Approach
文献类型：期刊论文
| 作者 | Wang, Jing2; Gu, Jiande2,3 ; Minh Tho Nguyen1; Springsteen, Greg4; Leszczynski, Jerzy2
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| 刊名 | JOURNAL OF PHYSICAL CHEMISTRY B
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| 出版日期 | 2013-11-14 |
| 卷号 | 117期号:45页码:14039-14045 |
| ISSN号 | 1520-6106 |
| DOI | 10.1021/jp409296k |
| 文献子类 | Article |
| 英文摘要 | Mechanisms for abiotic reaction pathways from formamide (H2NCHO) to adenine are presented herein. Formamide is a simple Cl building block hypothesized to be a precursor to many protometabolic compounds. On the basis of a step-by-step mechanism of the reaction pathways, formamide is suggested to be more reactive in addition reactions than HCN. In addition to its simplicity, the formamide self-catalyzed mechanism is energetically (kinetically) more viable than either a water-catalyzed mechanism or noncatalyzed processes. Moreover, this self-catalyzed mechanism accounts for the yields of purine and adenine previously observed in experiments. This mechanism may elucidate processes that were vital for the emergence of life on the early earth. |
| WOS关键词 | PRIMITIVE EARTH CONDITIONS ; PURINE RING FORMATION ; HYDROGEN-CYANIDE ; PREBIOTIC SYNTHESIS ; REACTION PATHWAY ; NUCLEIC-ACIDS ; ORIGIN ; MOLECULES ; LIFE ; NUCLEOBASES |
| 资助项目 | NSF[CHE1004570] ; NASA Astrobiology Program under the NSF Center for Chemical Evolution[CHE1004570] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000327111200011 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277379]  |
| 专题 | 药物发现与设计中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Gu, Jiande |
| 作者单位 | 1.Univ Louvain, Dept Chem, B-3001 Louvain, Belgium; 2.Jackson State Univ, Interdisciplinary Nanotox Ctr, Dept Chem & Biochem, Jackson, MS 39217 USA; 3.Chinese Acad Sci, Drug Design & Discovery Ctr, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 4.Furman Univ, Dept Chem, Greenville, SC 29613 USA |
| 推荐引用方式 GB/T 7714 | Wang, Jing,Gu, Jiande,Minh Tho Nguyen,et al. From Formamide to Adenine: A Self-Catalytic Mechanism for an Abiotic Approach[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2013,117(45):14039-14045. |
| APA | Wang, Jing,Gu, Jiande,Minh Tho Nguyen,Springsteen, Greg,&Leszczynski, Jerzy.(2013).From Formamide to Adenine: A Self-Catalytic Mechanism for an Abiotic Approach.JOURNAL OF PHYSICAL CHEMISTRY B,117(45),14039-14045. |
| MLA | Wang, Jing,et al."From Formamide to Adenine: A Self-Catalytic Mechanism for an Abiotic Approach".JOURNAL OF PHYSICAL CHEMISTRY B 117.45(2013):14039-14045. |
入库方式： OAI收割
来源：上海药物研究所
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