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Promising effects on ameliorating mitochondrial function and enhancing Akt signaling in SH-SY5Y cells by (M)-bicelaphanol A, a novel dimeric podocarpane type trinorditerpene isolated from Celastrus orbiculatus

文献类型：期刊论文

作者Wang, Xu Jie1; Wang, Luo Yi1; Fu, Yan1; Wu, Jian1; Tang, Xi Can1; Zhao, Wei Min1; Zhang, Hai Yan1,2
刊名PHYTOMEDICINE
出版日期2013-09-15
卷号20期号:12页码:1064-1070
关键词Celastrus orbiculatus (M)-bicelaphanol A Oxidative stress Neurodegenerative disease Hydrogen peroxide Mitochondria Apoptosis
ISSN号0944-7113
DOI10.1016/j.phymed.2013.04.017
文献子类Article
英文摘要Oxidative stress plays an important role in the pathological processes of various neurodegenerative diseases. In this study, we investigated the neuroprotective effects of (M)-bicelaphanol A, which has been the first dimeric podocarpane type trinorditerpene isolated from Celastrus orbiculatus, against hydrogen peroxide (H2O2)-induced injury in human SH-SY5Y neuroblastoma cells. Our study showed that cells pre-treated with (M)-bicelaphanol A significantly attenuated H2O2-induced cell viability reduction and cell apoptosis. These neuroprotective effects of (M)-bicelaphanol A were associated with a reduction of reactive oxygen species and an increase in the level of adenosine triphosphate. In addition, (M)-bicelaphanol A pretreatment markedly increased the phosphorylation level of Akt in SH-SY5Y cells. In conclusion, our results for the first time demonstrate that the protection of (M)-bicelaphanol A on SH-SY5Y cells against H2O2-induced oxidative stress may attribute, at least partially, to its attenuation of mitochondrial dysfunction and activation of Akt signaling pathway. Above results shed more light on the molecular mechanisms involved in the neuroprotective effects of (M)-bicelaphanol A, which could be a potential drug candidate for the treatment of oxidative stress-associated neurodegenerative diseases. (C) 2013 Elsevier GmbH. All rights reserved.
WOS关键词OXIDATIVE STRESS ; HYDROGEN-PEROXIDE ; NEURODEGENERATIVE DISEASES ; FREE-RADICALS ; ALZHEIMERS-DISEASE ; ANTIOXIDANTS ; ACTIVATION ; APOPTOSIS ; SURVIVAL ; BRAIN
资助项目Ministry of Science and Technology of China[2011CB510004] ; National Natural Science Foundation of China[81173034] ; National Natural Science Foundation of China[81072646] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program" of China[2011ZX09307-002-03] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program" of China[2012ZX09301001-001] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program" of China[2012ZX09301001-004] ; State Key Laboratory of Drug Research[SIMM1203KF-02]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种英语
WOS记录号WOS:000324453700004
出版者ELSEVIER GMBH, URBAN & FISCHER VERLAG
源URL[http://119.78.100.183/handle/2S10ELR8/277460]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
药理学第二研究室
通讯作者Zhao, Wei Min
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Beijing 100864, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Beijing 100864, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Xu Jie,Wang, Luo Yi,Fu, Yan,et al. Promising effects on ameliorating mitochondrial function and enhancing Akt signaling in SH-SY5Y cells by (M)-bicelaphanol A, a novel dimeric podocarpane type trinorditerpene isolated from Celastrus orbiculatus[J]. PHYTOMEDICINE,2013,20(12):1064-1070.
APA Wang, Xu Jie.,Wang, Luo Yi.,Fu, Yan.,Wu, Jian.,Tang, Xi Can.,...&Zhang, Hai Yan.(2013).Promising effects on ameliorating mitochondrial function and enhancing Akt signaling in SH-SY5Y cells by (M)-bicelaphanol A, a novel dimeric podocarpane type trinorditerpene isolated from Celastrus orbiculatus.PHYTOMEDICINE,20(12),1064-1070.
MLA Wang, Xu Jie,et al."Promising effects on ameliorating mitochondrial function and enhancing Akt signaling in SH-SY5Y cells by (M)-bicelaphanol A, a novel dimeric podocarpane type trinorditerpene isolated from Celastrus orbiculatus".PHYTOMEDICINE 20.12(2013):1064-1070.

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来源：上海药物研究所

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