Direct Olefination at the C-4 Position of Tryptophan via C-H Activation: Application to Biomimetic Synthesis of Clavicipitic Acid
文献类型：期刊论文
| 作者 | Liu, Qiang1; Li, Qingjiang1; Ma, Yongfan1; Jia, Yanxing1,2 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2013-09-06 |
| 卷号 | 15期号:17页码:4528-4531 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol4020877 |
| 文献子类 | Article |
| 英文摘要 | The first Pd-catalyzed method for direct olefination at the C4 position of tryptophan derivatives has been developed via C-H activation to prepare 4-substituted tryptophans, which could be used for the synthesis of many hemiterpenoid indole alkaloids. This reaction proceeds under mild reaction conditions and with exceptional tolerance to a variety of functional groups. Furthermore, the efficiency of this method is demonstrated by the rapid and biomimetic synthesis of clavicipitic acid. |
| WOS关键词 | ERGOT ALKALOIDS ; ENANTIOSELECTIVE SYNTHESIS ; 4-SUBSTITUTED INDOLES ; DIMETHYLALLYLTRYPTOPHAN SYNTHASE ; (-)-CIS-CLAVICIPITIC ACID ; BOND FUNCTIONALIZATION ; BIOLOGICAL EVALUATION ; EFFICIENT SYNTHESIS ; (+)-LYSERGIC ACID ; NATURAL-PRODUCTS |
| 资助项目 | National Natural Science Foundation of China[21290180] ; National Natural Science Foundation of China[20972007] ; National Basic Research Program of China (973 Program)[2010CB833200] ; State Key Laboratory of Drug Research[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000328864800065 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277465]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Jia, Yanxing |
| 作者单位 | 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Media, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Qiang,Li, Qingjiang,Ma, Yongfan,et al. Direct Olefination at the C-4 Position of Tryptophan via C-H Activation: Application to Biomimetic Synthesis of Clavicipitic Acid[J]. ORGANIC LETTERS,2013,15(17):4528-4531. |
| APA | Liu, Qiang,Li, Qingjiang,Ma, Yongfan,&Jia, Yanxing.(2013).Direct Olefination at the C-4 Position of Tryptophan via C-H Activation: Application to Biomimetic Synthesis of Clavicipitic Acid.ORGANIC LETTERS,15(17),4528-4531. |
| MLA | Liu, Qiang,et al."Direct Olefination at the C-4 Position of Tryptophan via C-H Activation: Application to Biomimetic Synthesis of Clavicipitic Acid".ORGANIC LETTERS 15.17(2013):4528-4531. |
入库方式： OAI收割
来源：上海药物研究所
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