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Mitochondrial Regulation in Pluripotent Stem Cells

文献类型：期刊论文

作者Xu, Xiuling1; Duan, Shunlei1; Yi, Fei2; Ocampo, Alejandro2; Liu, Guang-Hui1,3,4; Izpisua Belmonte, Juan Carlos2,5
刊名CELL METABOLISM
出版日期2013-09-03
卷号18期号:3页码:325-332
ISSN号1550-4131
DOI10.1016/j.cmet.2013.06.005
文献子类Review
英文摘要Due to their fundamental role in energy production, mitochondria have been traditionally known as the powerhouse of the cell. Recent discoveries have suggested crucial roles of mitochondria in the maintenance of pluripotency, differentiation, and reprogramming of induced pluripotent stem cells (iPSCs). While glycolytic energy production is observed at pluripotent states, an increase in mitochondrial oxidative phosphorylation is necessary for cell differentiation. Consequently, a transition from somatic mitochondrial oxidative metabolism to glycolysis seems to be required for successful reprogramming. Future research aiming to dissect the roles of mitochondria in the establishment and homeostasis of pluripotency, as well as combining cell reprogramming with gene editing technologies, may unearth novel insights into our understanding of mitochondrial diseases and aging.
WOS关键词ENERGY-METABOLISM ; DIFFERENTIATION ; MUTATIONS ; FUSION ; EMBRYOGENESIS ; MITOPHAGY ; DYNAMICS ; FISSION ; SWITCH ; DEATH
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDA01020312] ; NSFC[81271266] ; NSFC[31222039] ; NSFC[31201111] ; Thousand Young Talents program of China, National Laboratory of Bio-macromolecules[2013kf05] ; Thousand Young Talents program of China, National Laboratory of Bio-macromolecules[2013kf11] ; State Key Laboratory of Drug Research[SIMM1302KF-17] ; TERCEL-ISCIII-MINECO[00000000] ; Fundacion Cellex[00000000] ; G. Harold and Leila Y. Mathers Charitable Foundation[00000000] ; The Leona M. and Harry B. Helmsley Charitable Trust[00000000] ; Glenn Center for Aging Research[00000000] ; Ellison Medical Foundation[00000000]
WOS研究方向Cell Biology ; Endocrinology & Metabolism
语种英语
WOS记录号WOS:000326267300006
出版者CELL PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/277468]  
专题新药研究国家重点实验室
中科院受体结构与功能重点实验室
通讯作者Liu, Guang-Hui
作者单位1.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China;
2.Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA;
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
4.Beijing Inst Brain Disorders, Beijing, Peoples R China;
5.Ctr Regenerat Med Barcelona, Barcelona 08003, Spain
推荐引用方式
GB/T 7714		 Xu, Xiuling,Duan, Shunlei,Yi, Fei,et al. Mitochondrial Regulation in Pluripotent Stem Cells[J]. CELL METABOLISM,2013,18(3):325-332.
APA Xu, Xiuling,Duan, Shunlei,Yi, Fei,Ocampo, Alejandro,Liu, Guang-Hui,&Izpisua Belmonte, Juan Carlos.(2013).Mitochondrial Regulation in Pluripotent Stem Cells.CELL METABOLISM,18(3),325-332.
MLA Xu, Xiuling,et al."Mitochondrial Regulation in Pluripotent Stem Cells".CELL METABOLISM 18.3(2013):325-332.

入库方式： OAI收割

来源：上海药物研究所

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