Heparanase expression correlates with poor survival in oral mucosal melanoma
文献类型：期刊论文
| 作者 | Wang, Xin2 ; Wen, Weiwei3; Wu, Heming1; Chen, Yi3; Ren, Guoxin4; Guo, Wei4
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| 刊名 | MEDICAL ONCOLOGY
 |
| 出版日期 | 2013-09 |
| 卷号 | 30期号:3 |
| 关键词 | Heparanase Oral mucosal melanoma Survival Staining Localization |
| ISSN号 | 1357-0560 |
| DOI | 10.1007/s12032-013-0633-5 |
| 文献子类 | Article |
| 英文摘要 | Oral mucosal melanoma (OMM) is a lethal cancer with a poor prognosis. Despite the great interest in heparanase (HPSE) as a potential anticancer therapy target, the prognostic role of HPSE in oral mucosal melanoma has not been elucidated. In this study, we investigated HPSE expression in OMM tissues and examined its association with clinical outcome. A total of 81 patients with OMM were enrolled in this study. We examined the expression of HPSE in OMM, and its staining extent, intensity and cellular localization were analyzed for clinical significance. HPSE staining was positive in 81 % of tumors (66 of 81 patients) and was negative in the remaining 19 % (15 patients). The median survival time and the 5-year survival rate were 12 months and 7.0 % in the high-heparanase group, 35 months and 36.4 % in the low-heparanase group and 62 months and 53.3 % in the none-heparanase group (P = 0.001). In univariate survival analysis of oral mucosal melanoma, AJCC Stage, heparanase level, heparanase location and tumor size were the clinical parameters related to overall survival. In Cox analysis, overall survival time was significantly dependent on AJCC stage and heparanase level, but not tumor size and heparanase location. Heparanase is frequently expressed in oral mucosal melanoma, and its expression levels inversely correlate with the survival rates of OMM patients, clearly indicating that heparanase is a reliable prognostic factor for this malignancy and an attractive target for anticancer drug development. |
| WOS关键词 | CANCER METASTASIS ; PATIENT SURVIVAL ; HEAD ; ANGIOGENESIS ; PROGRESSION ; NECK ; LOCALIZATION ; PROGNOSIS |
| 资助项目 | Project of Science and Technology Commission of Shanghai Municipality[10410711200] ; Project of Science and Technology Commission of Shanghai Municipality[08140902100] ; Project of Science and Technology Commission of Shanghai Municipality[11495802000] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000323662900052 |
| 出版者 | HUMANA PRESS INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277483]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Xin |
| 作者单位 | 1.Nanjing Med Univ, Dept Oral & Maxillofacial Surg, Inst Stomatol, Nanjing, Jiangsu, Peoples R China; 2.Nanjing Med Univ, Affiliated Wuxi Peoples Hosp, Dept Oral & Maxillofacial Surg, Wuxi City 214023, Jiangsu, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 200031, Peoples R China; 4.Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Oral & Maxillofacial Head & Neck Oncol, Sch Med, Shanghai 200011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xin,Wen, Weiwei,Wu, Heming,et al. Heparanase expression correlates with poor survival in oral mucosal melanoma[J]. MEDICAL ONCOLOGY,2013,30(3). |
| APA | Wang, Xin,Wen, Weiwei,Wu, Heming,Chen, Yi,Ren, Guoxin,&Guo, Wei.(2013).Heparanase expression correlates with poor survival in oral mucosal melanoma.MEDICAL ONCOLOGY,30(3). |
| MLA | Wang, Xin,et al."Heparanase expression correlates with poor survival in oral mucosal melanoma".MEDICAL ONCOLOGY 30.3(2013). |
入库方式： OAI收割
来源：上海药物研究所
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