Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors
文献类型：期刊论文
| 作者 | Liang, Lin-Fu1; Gao, Li-Xin1; Li, Jia1 ; Taglialatela-Scafati, Orazio2; Guo, Yue-Wei1
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2013-09-01 |
| 卷号 | 21期号:17页码:5076-5080 |
| 关键词 | Cembrane Marinde diterpenoids Sarcophyton trocheliophorum PTP1B inhibition |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/j.bmc.2013.06.043 |
| 文献子类 | Article |
| 英文摘要 | A detailed investigation of the South China Sea soft coral Sarcophyton trocheliophorum Marenzeller yielded, along with six known terpenes (6-11), the new sarcophytonolides N-R (1-5), whose structures have been elucidated by detailed spectroscopic analysis. Sarcophytonolides N-R are mono- or bicyclic cembranoids characterized by the presence of three/four double bonds and oxidized methyl groups. Some of the isolated compounds showed significant inhibitory activity against human protein tyrosine phosphatase 1B (PTP1B) enzyme, a key target for the treatment of type-II diabetes and obesity, and some preliminary structure-activity relationships have been drawn. This is the first report on the anti-PTP1B activity of cembrane diterpenoids. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved. |
| WOS关键词 | NATURAL-PRODUCTS ; PHOSPHATASE ; DISCOVERY |
| 资助项目 | Natural Science Foundation of China[21072204] ; Natural Science Foundation of China[21021063] ; Natural Science Foundation of China[81273430] ; National Marine '863' Project[2011AA09070102] ; National Marine '863' Project[2013AA092902] ; SKLDR/SIMM[SIMM1203ZZ-03] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000323294600023 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277484]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 国家新药筛选中心 |
| 通讯作者 | Taglialatela-Scafati, Orazio |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Univ Naples Federico II, Dipartimento Farm, I-80131 Naples, Italy |
| 推荐引用方式 GB/T 7714 | Liang, Lin-Fu,Gao, Li-Xin,Li, Jia,et al. Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2013,21(17):5076-5080. |
| APA | Liang, Lin-Fu,Gao, Li-Xin,Li, Jia,Taglialatela-Scafati, Orazio,&Guo, Yue-Wei.(2013).Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors.BIOORGANIC & MEDICINAL CHEMISTRY,21(17),5076-5080. |
| MLA | Liang, Lin-Fu,et al."Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY 21.17(2013):5076-5080. |
入库方式： OAI收割
来源：上海药物研究所
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