中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 国家新药筛选中心
Supplementation of the maternal diet during pregnancy with chocolate and fructose interacts with the high-fat diet of the young to facilitate the onset of metabolic disorders in rat offspring

文献类型：期刊论文

作者Zhang, Zhi-Yun1; Dai, Yun-Bin2; Wang, Hao-Nan1; Wang, Ming-Wei1,2
刊名CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
出版日期2013-09
卷号40期号:9页码:652-661
关键词chocolate fat metabolism fructose liver impairment maternal supplemental diet metabolic programming rat
ISSN号1440-1681
DOI10.1111/1440-1681.12147
文献子类Article
英文摘要1. Obesity and non-alcoholic fatty liver disease are the most common metabolic disorders in society today. Previously, we found that supplementing the maternal diet during pregnancy with chocolate and fructose has negative effects on the wellbeing of the offspring that were ameliorated if the offspring were fed a normal diet during postnatal life. In the present study, we investigated whether feeding offspring a high-fat diet would augment the maternal programming effects and whether extra protein supply can correct the low birth weight resulting from the chocolate-supplemented maternal diet. 2. Pregnant Sprague-Dawley rats were divided into three groups and fed either standard chow (normal nutrition; NN), chocolate-and fructose-supplemented standard chow with casein sodium (overnutrition; ON) or the supplemented standard chow without casein sodium (malnutrition; MN) throughout pregnancy. Male offspring were weaned on either standard or high-fat chow. 3. Dams in the MN group exhibited moderate weight gain, consumed 50% less protein (P < 0.001) but more carbohydrates during gestation and delivered pups with a 12% lower birth weight (P < 0.05) than pups in the NN group, results that are consistent with previous findings. When fed on a high-fat diet after birth, pups from dams in the MN group (MNHD) had 30% more body fat (P = 0.023) and liver triglyceride (TG) levels that were double (P < 0.01) those in offspring in the other groups, leading to fatty livers in these offspring at 14 weeks of age. Hepatic expression of the PPARa, ApoB100, MTTP, CPT1 and SREBP1c genes was significantly downregulated in the MNHD group (P < 0.05 for all), indicating changes in lipid metabolism. Although dams in the ON group exhibited marked gestational weight gain (P < 0.01), they gave birth to normal weight pups that only manifested mild increases in body fat and liver TG content (P < 0.05), without significant changes in the expression of most genes when fed with the high-fat diet. 4. The results suggest that the extra protein supply in the form of casein sodium was able to correct some negative programming effects of the chocolate and fructose supplementation of the maternal diet, which, in conjunction with a highfat diet in the offspring, may facilitate the onset of metabolic disorders, with impaired liver gene expression possibly a key contributor.
WOS关键词LOW-PROTEIN DIET ; LIVER-DISEASE ; GENE-EXPRESSION ; NUTRITION ; GESTATION ; FETAL ; STEATOHEPATITIS ; MITOCHONDRIAL ; RESTRICTION ; MECHANISMS
资助项目Ministry of Health of China[2012ZX09304011] ; Ministry of Health of China[2013ZX09507002] ; Shanghai Science and Technology Development Fund[11DZ2292200] ; CAS-Novo Nordisk Research Fund[00000000]
WOS研究方向Pharmacology & Pharmacy ; Physiology
语种英语
WOS记录号WOS:000323376800010
出版者WILEY-BLACKWELL
源URL[http://119.78.100.183/handle/2S10ELR8/277491]  
专题国家新药筛选中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Wang, Ming-Wei
作者单位1.Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Chinese Natl Compound Lib, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Zhi-Yun,Dai, Yun-Bin,Wang, Hao-Nan,et al. Supplementation of the maternal diet during pregnancy with chocolate and fructose interacts with the high-fat diet of the young to facilitate the onset of metabolic disorders in rat offspring[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2013,40(9):652-661.
APA Zhang, Zhi-Yun,Dai, Yun-Bin,Wang, Hao-Nan,&Wang, Ming-Wei.(2013).Supplementation of the maternal diet during pregnancy with chocolate and fructose interacts with the high-fat diet of the young to facilitate the onset of metabolic disorders in rat offspring.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,40(9),652-661.
MLA Zhang, Zhi-Yun,et al."Supplementation of the maternal diet during pregnancy with chocolate and fructose interacts with the high-fat diet of the young to facilitate the onset of metabolic disorders in rat offspring".CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 40.9(2013):652-661.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。