Selective Synthesis of 5,6-Dihydroindolo[1,2-a]quinoxalines and 6,7-Dihydroindolo[2,3-c]quinolines by Orthogonal Copper and Palladium Catalysis
文献类型：期刊论文
| 作者 | Zhang, Lei; Zhao, Fei; Zheng, Mingyue ; Zhai, Yun; Wang, Jiang; Liu, Hong
|
| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2013-09 |
| 卷号 | 2013期号:25页码:5710-5715 |
| 关键词 | Multicomponent reactions Fused-ring systems Nitrogen heterocycles Microwave chemistry Palladium Copper |
| ISSN号 | 1434-193X |
| DOI | 10.1002/ejoc.201300667 |
| 文献子类 | Article |
| 英文摘要 | In combination with the Ugi four-component reaction, two important indole-fused heterocycles have been prepared in two steps from readily accessible starting materials. From the same set of Ugi adducts 5, 5,6-dihydroindolo[1,2-a]quinoxalines 6 were rapidly generated in excellent yields by a copper-catalyzed N-H arylation pathway, whereas 6,7-dihydroindolo[2,3-c]quinolones 7 were obtained by palladium-catalyzed C-H arylations in good yields without the protection of the indole N1 moiety. Microwave heating was used to accelerate these intramolecular C-N and C-C bond-forming reactions performed under controlled reaction conditions. |
| WOS关键词 | DIVERSITY-ORIENTED-SYNTHESIS ; ARYL BOND FORMATION ; C-H ; MULTICOMPONENT REACTIONS ; FUSED HETEROCYCLES ; DIRECT ARYLATION ; DRUG DISCOVERY ; UGI-ADDUCTS ; SINGLE SET ; INDOLE |
| 资助项目 | National Natural Science Foundation of China (NSFC)[21021063] ; National Natural Science Foundation of China (NSFC)[91229204] ; National Natural Science Foundation of China (NSFC)[81025017] ; National S&T Major Projects[2012ZX09103101-072] ; National S&T Major Projects[2012ZX09301001-005] ; China-EU Science and Technology Co-operation Project[1109] ; Silver Project[260644] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000323319500023 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277492]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第二研究室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Lei,Zhao, Fei,Zheng, Mingyue,et al. Selective Synthesis of 5,6-Dihydroindolo[1,2-a]quinoxalines and 6,7-Dihydroindolo[2,3-c]quinolines by Orthogonal Copper and Palladium Catalysis[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2013,2013(25):5710-5715. |
| APA | Zhang, Lei,Zhao, Fei,Zheng, Mingyue,Zhai, Yun,Wang, Jiang,&Liu, Hong.(2013).Selective Synthesis of 5,6-Dihydroindolo[1,2-a]quinoxalines and 6,7-Dihydroindolo[2,3-c]quinolines by Orthogonal Copper and Palladium Catalysis.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2013(25),5710-5715. |
| MLA | Zhang, Lei,et al."Selective Synthesis of 5,6-Dihydroindolo[1,2-a]quinoxalines and 6,7-Dihydroindolo[2,3-c]quinolines by Orthogonal Copper and Palladium Catalysis".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2013.25(2013):5710-5715. |
入库方式： OAI收割
来源：上海药物研究所
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