Casuarinines A-J, Lycodine-Type Alkaloids from Lycopodiastrum casuarinoides
文献类型：期刊论文
| 作者 | Tang, Yu1; Fu, Yan2; Xiong, Juan1; Li, Ming1 ; Ma, Guang-Lei1; Yang, Guo-Xun1; Wei, Bang-Guo3; Zhao, Yun4; Zhang, Hai-Yan2; Hu, Jin-Feng1
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2013-08 |
| 卷号 | 76期号:8页码:1475-1484 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np4003355 |
| 文献子类 | Article |
| 英文摘要 | Ten new lycodine-type alkaloids, named casuarinines A-J (1-10), along with eight known analogues (11-18), were isolated from the whole plant of Lycopodiastrum casuarinoides. The new structures were established by spectroscopic methods and chemical transformations. Casuarinines A-D (1-4) and J (10) are common lycodine alkaloids possessing four connected six-membered rings, while tricyclic casuarinines E-H (5-8) are the piperidine ring cleavage products. In particular, casuarinine I (9) has an unprecedented five-membered tetrahydropyrrole ring instead of the piperidine ring. A plausible biosynthetic pathway to 9 is proposed. Among the compounds reported, casuarinine H (8) exhibited significant neuroprotective effect against hydrogen peroxide (H2O2)-induced neuronal cell damage in human neuroblastoma SH-SYSY cells, while casuarinines C (3) and I (9) showed moderate inhibitory activity against acetylcholinesterase (AChE). |
| WOS关键词 | HUPERZINE-A ; INHIBITING ACETYLCHOLINESTERASE ; COMPLANATUM |
| 资助项目 | NSFC[81273401] ; NSFC[81202420] ; STCSM[11DZ1921203] ; Ph.D. Programs Foundation of Ministry of Education (MOE) of China[20120071110049] ; Ph.D. Programs Foundation of Ministry of Education (MOE) of China[20120071120049] ; MOST[2011ZX09307-002-01] ; National Basic Research Program of China (973 Program)[2013CB530700] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000323630500012 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277515]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Hu, Jin-Feng |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Prod Chem, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Fudan Univ, Dept Chem, Shanghai 200032, Peoples R China; 4.E China Normal Univ, Min Educ, Dept Nat Prod Chem Genet Res, Key Lab Brain Funct Genom, Shanghai 200062, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Yu,Fu, Yan,Xiong, Juan,et al. Casuarinines A-J, Lycodine-Type Alkaloids from Lycopodiastrum casuarinoides[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(8):1475-1484. |
| APA | Tang, Yu.,Fu, Yan.,Xiong, Juan.,Li, Ming.,Ma, Guang-Lei.,...&Hu, Jin-Feng.(2013).Casuarinines A-J, Lycodine-Type Alkaloids from Lycopodiastrum casuarinoides.JOURNAL OF NATURAL PRODUCTS,76(8),1475-1484. |
| MLA | Tang, Yu,et al."Casuarinines A-J, Lycodine-Type Alkaloids from Lycopodiastrum casuarinoides".JOURNAL OF NATURAL PRODUCTS 76.8(2013):1475-1484. |
入库方式： OAI收割
来源：上海药物研究所
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