Differential expression of Arc in the mesocorticolimbic system is involved in drug and natural rewarding behavior in rats
文献类型：期刊论文
| 作者 | Li, Mu1; Liu, Wen-jie1; Lu, Bin1; Wang, Yu-hua1,2; Liu, Jing-gen1
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| 刊名 | ACTA PHARMACOLOGICA SINICA
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| 出版日期 | 2013-08 |
| 卷号 | 34期号:8页码:1013-1024 |
| 关键词 | addiction drug reinforcement the runway model Arc/Arg3.1 medial prefrontal cortex striatum heroin MK801 SCH23390 |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2013.28 |
| 文献子类 | Article |
| 英文摘要 | Aim: To investigate the different effects of heroin and milk in activating the corticostriatal system that plays a critical role in reward reinforcement learning. Methods: Male SD rats were trained daily for 15 d to self-administer heroin or milk tablets in a classic runway drug self-administration model. Immunohistochemical assay was used to quantify Arc protein expression in the medial prefrontal cortex (mPFC), the nucleus accumbens (NAc), the dorsomedial striatum (DMS) and the ventrolateral striatum (VLS) in response to chronic self-administration of heroin or milk tablets. NMDA receptor antagonist MK801 (0.1 mg/kg) or dopamine D1 receptor antagonist SCH23390 (0.03 mg/kg) were intravenously injected at the same time as heroin was infused intravenously. Results: Runway training with heroin resulted in robust enhancement of Arc expression in the mPFC, the NAc and the DMS on d 1, 7, and 15, and in the VLS on d 1 and d 7. However, runway training with milk led to increased Arc expression in the mPFC, the NAc and the DMS only on d 7 and/or d 15 but not on d 1. Moreover, runway training with milk failed to induce increased Arc protein in the VLS. Both heroin-seeking behavior and Arc protein expression were blocked by MK801 or SCH23390 administration. Conclusion: The VLS is likely to be critically involved in drug-seeking behavior. The NMDA-and D1 receptor-dependent Arc expression is important in drug-seeking behavior. |
| WOS关键词 | COCAINE-SEEKING BEHAVIOR ; NUCLEUS-ACCUMBENS CORE ; MEDIAL PREFRONTAL CORTEX ; LONG-TERM POTENTIATION ; DORSAL STRIATUM ; SYNAPTIC PLASTICITY ; BASAL GANGLIA ; DOPAMINE ANTAGONISTS ; PROTEIN EXPRESSION ; PROGRESSIVE-RATIO |
| 资助项目 | National Basic Research Program, a grant from the Ministry of Science and Technology of China[2009CB522005] ; National Natural Science Foundation of China[81130087] ; National Natural Science Foundation of China[91232716] ; Foundation of Natural Science of Jiangshu Province[SBK201241521] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000322709400005 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277518]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 天然药物化学研究室 |
| 通讯作者 | Liu, Jing-gen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210046, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Mu,Liu, Wen-jie,Lu, Bin,et al. Differential expression of Arc in the mesocorticolimbic system is involved in drug and natural rewarding behavior in rats[J]. ACTA PHARMACOLOGICA SINICA,2013,34(8):1013-1024. |
| APA | Li, Mu,Liu, Wen-jie,Lu, Bin,Wang, Yu-hua,&Liu, Jing-gen.(2013).Differential expression of Arc in the mesocorticolimbic system is involved in drug and natural rewarding behavior in rats.ACTA PHARMACOLOGICA SINICA,34(8),1013-1024. |
| MLA | Li, Mu,et al."Differential expression of Arc in the mesocorticolimbic system is involved in drug and natural rewarding behavior in rats".ACTA PHARMACOLOGICA SINICA 34.8(2013):1013-1024. |
入库方式： OAI收割
来源：上海药物研究所
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