Isomalabaricane triterpenes with potent protein-tyrosine phosphatase 1B (PTP1B) inhibition from the Hainan sponge Stelletta sp.
文献类型：期刊论文
| 作者 | Xue, Duo-Qing1; Mao, Shui-Chun2; Yu, Xiao-Qing2; Guo, Yue-Wei1
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| 刊名 | BIOCHEMICAL SYSTEMATICS AND ECOLOGY
 |
| 出版日期 | 2013-08 |
| 卷号 | 49页码:101-106 |
| 关键词 | Sponge Stelletta sp. Isomalabaricane triterpenes Cytotoxicity PTP1B inhibitor |
| ISSN号 | 0305-1978 |
| DOI | 10.1016/j.bse.2013.03.001 |
| 文献子类 | Article |
| 英文摘要 | A new isomalabaricane triterpene, stellettin N (1), has been isolated together with five known analogues, stellettin H (2), rhabdastrellic acid A (3), stellettin G (4), stellettin D (5), and 22,23-dihydrostellettin D (6), from the Hainan sponge Stelletta sp. The structure of 1 was elucidated on the basis of detailed spectroscopic analysis of its methyl ester (7) and by comparison of NMR data of 7 with those of related known compounds. Compounds 3-8 were evaluated for their inhibitory activity against hPTP1B and the result showed compound 4 had a strong hPTP1B inhibitory activity with IC50 value of 4.1 +/- 0.9 mu M. Compound 4 also exhibited weak cytotoxicity against A549 and HL-60 cells at a concentration of 10 mu M. Furthermore, the chemotaxonomic significance of these compounds was also summarized. (c) 2013 Elsevier Ltd. All rights reserved. |
| WOS关键词 | MARINE SPONGE ; RHABDASTRELLA-GLOBOSTELLATA ; MYRIASTRA-CLAVOSA ; A-C ; SESQUITERPENES ; NORTRITERPENOIDS ; CONSTITUENTS ; VARIABILIS ; ALKALOIDS ; PIGMENT |
| 资助项目 | National Marine 863 Project[2013AA092902] ; Natural Science Foundation of China[81273430] ; Natural Science Foundation of China[21021063] ; Natural Science Foundation of China[21162016] ; Natural Science Foundation of China[30730108] ; Natural Science Foundation of China[20862013] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Environmental Sciences & Ecology ; Evolutionary Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000321407700017 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277526]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Guo, Yue-Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Nanchang Univ, Sch Pharm, Nanchang 330006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xue, Duo-Qing,Mao, Shui-Chun,Yu, Xiao-Qing,et al. Isomalabaricane triterpenes with potent protein-tyrosine phosphatase 1B (PTP1B) inhibition from the Hainan sponge Stelletta sp.[J]. BIOCHEMICAL SYSTEMATICS AND ECOLOGY,2013,49:101-106. |
| APA | Xue, Duo-Qing,Mao, Shui-Chun,Yu, Xiao-Qing,&Guo, Yue-Wei.(2013).Isomalabaricane triterpenes with potent protein-tyrosine phosphatase 1B (PTP1B) inhibition from the Hainan sponge Stelletta sp..BIOCHEMICAL SYSTEMATICS AND ECOLOGY,49,101-106. |
| MLA | Xue, Duo-Qing,et al."Isomalabaricane triterpenes with potent protein-tyrosine phosphatase 1B (PTP1B) inhibition from the Hainan sponge Stelletta sp.".BIOCHEMICAL SYSTEMATICS AND ECOLOGY 49(2013):101-106. |
入库方式： OAI收割
来源：上海药物研究所
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