Synthesis of the melatonin receptor agonist Ramelteon using a tandem C-H activation-alkylation/Heck reaction and subsequent asymmetric Michael addition
文献类型：期刊论文
| 作者 | Fu, XiaoDan2; Guo, XingQun2; Li, XingWei2; He, LiDong2; Yang, YuShe1 ; Chen, YouXi2
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| 刊名 | TETRAHEDRON-ASYMMETRY
 |
| 出版日期 | 2013-07-31 |
| 卷号 | 24期号:13-14页码:827-832 |
| ISSN号 | 0957-4166 |
| DOI | 10.1016/j.tetasy.2013.05.006 |
| 文献子类 | Article |
| 英文摘要 | An asymmetric synthesis of the melatonin receptor agonist Ramelteon 1 has been achieved, which involved a tandem C H activation-alkylation/Heck reaction and subsequent highly diastereoselective asymmetric Michael addition to generate the corresponding chiral intermediate, which was readily converted into Ramelteon 1 in 19% overall yield in 15 linear steps. (C) 2013 Published by Elsevier Ltd. |
| WOS关键词 | STEREOSELECTIVE-SYNTHESIS ; INDAN DERIVATIVES ; NEURAL-CONTROL ; HYDROGENATION ; SERIES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000322610500009 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277530]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, YuShe |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Shanghai Sun Sail Pharmaceut Sci & Technol Co Ltd, Dept Med Chem, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Fu, XiaoDan,Guo, XingQun,Li, XingWei,et al. Synthesis of the melatonin receptor agonist Ramelteon using a tandem C-H activation-alkylation/Heck reaction and subsequent asymmetric Michael addition[J]. TETRAHEDRON-ASYMMETRY,2013,24(13-14):827-832. |
| APA | Fu, XiaoDan,Guo, XingQun,Li, XingWei,He, LiDong,Yang, YuShe,&Chen, YouXi.(2013).Synthesis of the melatonin receptor agonist Ramelteon using a tandem C-H activation-alkylation/Heck reaction and subsequent asymmetric Michael addition.TETRAHEDRON-ASYMMETRY,24(13-14),827-832. |
| MLA | Fu, XiaoDan,et al."Synthesis of the melatonin receptor agonist Ramelteon using a tandem C-H activation-alkylation/Heck reaction and subsequent asymmetric Michael addition".TETRAHEDRON-ASYMMETRY 24.13-14(2013):827-832. |
入库方式： OAI收割
来源：上海药物研究所
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