Application of Epigenome-Modifying Small Molecules in Induced Pluripotent Stem Cells
文献类型：期刊论文
| 作者 | Lu, Junyan1,2; Kong, Xiangqian1,3; Luo, Cheng1,2 ; Li, Keqin Kathy3
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| 刊名 | MEDICINAL RESEARCH REVIEWS
 |
| 出版日期 | 2013-07 |
| 卷号 | 33期号:4页码:790-822 |
| 关键词 | induced pluripotent stem cells epigenetics DNA methylation histone modification small molecule inhibitor |
| ISSN号 | 0198-6325 |
| DOI | 10.1002/med.21265 |
| 文献子类 | Review |
| 英文摘要 | Recent breakthroughs in generating induced pluripotent stem cells (iPSCs) using four defined factors have revealed the potential utility of stem cells in biological research and clinical applications. However, the low efficiency and slow kinetics of reprogramming related to producing these cells and underlying safety issues, such as viral integration and genetic and epigenetic abnormalities of iPSCs, hamper the further application of iPSCs in laboratory and clinical settings. Previous studies have suggested that reprogramming efficiency can be enhanced and that reprogramming kinetics can be accelerated by manipulating epigenetic status. Herein, we review recent studies on the application of epigenome-modifying small molecules in enhancing reprogramming and functionally replacing some reprogramming factors. We mainly focus on studies that have used small molecules to interfere with epigenome-modifying enzymes, such as DNA methyltransferase, histone acetyltransferase, and histone methyltransferase. The potential use of these small molecules in inducing iPSCs and new ways to identify small molecules of higher potency and fewer side effects are also discussed. |
| WOS关键词 | HISTONE-H3 LYSINE-9 METHYLATION ; DNA METHYLATION ; DEACETYLASE INHIBITORS ; EPIGENETIC REGULATION ; CHROMATIN-STRUCTURE ; HUMAN FIBROBLASTS ; GENE-EXPRESSION ; VALPROIC ACID ; SENDAI-VIRUS ; ACETYLATION |
| 资助项目 | State Key Program of Basic Research of China[2009CB918502] ; State Key Program of Basic Research of China[2011CB510102] ; National Natural Science Foundation of China[20972174] ; National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[91029704] ; 863 program[2012AA020302] ; Chinese Academy of Sciences[XDA01040305] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000319988700003 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277575]  |
| 专题 | 药物发现与设计中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Li, Keqin Kathy |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, Shanghai 200031, Peoples R China; 2.Soochow Univ, Sch Elect & Informat Engn, Ctr Syst Biol, Suzhou, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, State Key Lab Med Genom, Shanghai Inst Hematol,Rui Jin Hosp, Shanghai 200030, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Junyan,Kong, Xiangqian,Luo, Cheng,et al. Application of Epigenome-Modifying Small Molecules in Induced Pluripotent Stem Cells[J]. MEDICINAL RESEARCH REVIEWS,2013,33(4):790-822. |
| APA | Lu, Junyan,Kong, Xiangqian,Luo, Cheng,&Li, Keqin Kathy.(2013).Application of Epigenome-Modifying Small Molecules in Induced Pluripotent Stem Cells.MEDICINAL RESEARCH REVIEWS,33(4),790-822. |
| MLA | Lu, Junyan,et al."Application of Epigenome-Modifying Small Molecules in Induced Pluripotent Stem Cells".MEDICINAL RESEARCH REVIEWS 33.4(2013):790-822. |
入库方式： OAI收割
来源：上海药物研究所
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