The discovery of colchicine-SAHA hybrids as a new class of antitumor agents
文献类型：期刊论文
| 作者 | Zhang, Xuan2 ; Zhang, Jie1; Tong, Linjiang1; Luo, Yu2; Su, Mingbo1; Zang, Yi1; Li, Jia1; Lu, Wei2; Chen, Yi1
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2013-06-01 |
| 卷号 | 21期号:11页码:3240-3244 |
| 关键词 | Colchicine SAHA HDAC Tubulin Hybrid |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/j.bmc.2013.03.049 |
| 文献子类 | Article |
| 英文摘要 | A novel class of colchicine-SAHA hybrids were designed and synthesised based on the synergistic antitumor effect of tubulin inhibitors and histone deacetylases (HDAC) inhibitors. To the best of our knowledge, this is the first design of molecules that are dual inhibitors of tubulin and HDAC. Biological evaluations of these compounds included the inhibitory activity of HDAC, in vitro cell cycle analysis in BEL-7402 cells as well as cytotoxicity in five cancer cell lines. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS关键词 | HISTONE DEACETYLASE INHIBITORS ; GROWTH-FACTOR RECEPTOR ; T-CELL LYMPHOMA ; CANCER-CELLS ; IN-VIVO ; TUBULIN POLYMERIZATION ; BIOLOGICAL EVALUATION ; ANTICANCER ACTIVITY ; POTENT INHIBITORS ; INDUCED APOPTOSIS |
| 资助项目 | State Key Laboratory of Drug Research[SIMM1203KF-10] ; National Natural Science Foundation of China[81172936] ; National Natural Science Foundation of China[21102046] ; Fundamental Research Funds for the Central Universities[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000319002600044 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277604]  |
| 专题 | 药理学第一研究室 中国科学院上海药物研究所 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 国家新药筛选中心 |
| 通讯作者 | Lu, Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, SIBS, Shanghai 201203, Peoples R China 2.E China Normal Univ, Inst Drug Discovery & Dev, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Shanghai 200062, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Xuan,Zhang, Jie,Tong, Linjiang,et al. The discovery of colchicine-SAHA hybrids as a new class of antitumor agents[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2013,21(11):3240-3244. |
| APA | Zhang, Xuan.,Zhang, Jie.,Tong, Linjiang.,Luo, Yu.,Su, Mingbo.,...&Chen, Yi.(2013).The discovery of colchicine-SAHA hybrids as a new class of antitumor agents.BIOORGANIC & MEDICINAL CHEMISTRY,21(11),3240-3244. |
| MLA | Zhang, Xuan,et al."The discovery of colchicine-SAHA hybrids as a new class of antitumor agents".BIOORGANIC & MEDICINAL CHEMISTRY 21.11(2013):3240-3244. |
入库方式： OAI收割
来源：上海药物研究所
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