Au(I)/Ag(I)-Catalyzed Cascade Approach for the Synthesis of Benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinones
文献类型：期刊论文
| 作者 | Ji, Xun1,2; Zhou, Yu1 ; Wang, Jinfang1; Zhao, Linxiang2; Jiang, Hualiang1,2; Liu, Hong1
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2013-05-03 |
| 卷号 | 78期号:9页码:4312-4318 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/jo400228g |
| 文献子类 | Article |
| 英文摘要 | An efficient and facile Au(I)/Ag(I)-catalyzed cascade method has been developed for one-pot synthesis of the complex polycylic heterocycles benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinone derivatives through treatment of the substituted 2-(1H-benzo[d]imidazol-2-yl)anilines with 4-pentynoic acid or 5-hexynoic acid. The strategy features a Au(I)/Ag(I)-catalyzed one-pot cascade process involving the formation of three new C-N bonds in high yields, and with broad a substrate scope. |
| WOS关键词 | RECEPTOR TYROSINE KINASE ; DIPEPTIDYL PEPTIDASE-IV ; CONCISE TOTAL-SYNTHESIS ; GOLD CATALYSIS ; BIOLOGICAL EVALUATION ; EFFICIENT SYNTHESIS ; ANTITUMOR AGENTS ; INHIBITOR ; POTENT ; DERIVATIVES |
| 资助项目 | National Basic Research Program of China[2009CB940903] ; National Basic Research Program of China[2009CB918502] ; National Basic Research Program of China[2012CB518005] ; National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[91229204] ; National Natural Science Foundation of China[81025017] ; National Natural Science Foundation of China[81102307] ; National S&T Major Projects[2012ZX09103-101-072] ; China-EU Science and Technology Cooperation Project[1109] ; Silver Project[260644] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000318588800012 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277623]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第一研究室 |
| 通讯作者 | Zhou, Yu |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Xun,Zhou, Yu,Wang, Jinfang,et al. Au(I)/Ag(I)-Catalyzed Cascade Approach for the Synthesis of Benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinones[J]. JOURNAL OF ORGANIC CHEMISTRY,2013,78(9):4312-4318. |
| APA | Ji, Xun,Zhou, Yu,Wang, Jinfang,Zhao, Linxiang,Jiang, Hualiang,&Liu, Hong.(2013).Au(I)/Ag(I)-Catalyzed Cascade Approach for the Synthesis of Benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinones.JOURNAL OF ORGANIC CHEMISTRY,78(9),4312-4318. |
| MLA | Ji, Xun,et al."Au(I)/Ag(I)-Catalyzed Cascade Approach for the Synthesis of Benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinones".JOURNAL OF ORGANIC CHEMISTRY 78.9(2013):4312-4318. |
入库方式： OAI收割
来源：上海药物研究所
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