Caulerprenylols A and B, two rare antifungal prenylated para-xylenes from the green alga Caulerpa racemosa
文献类型：期刊论文
| 作者 | Liu, Ai-Hong3; Liu, Ding-Quan4; Liang, Tong-Jun1; Yu, Xiao-Qing4; Feng, Mei-Tang4; Yao, Li-Gong2; Fang, Yi4; Wang, Bin4; Feng, Li-Hua4; Zhang, Min-Xian4 |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2013-05-01 |
| 卷号 | 23期号:9页码:2491-2494 |
| 关键词 | Green alga Caulerpa racemosa Prenylated xylenes Caulerprenylols A and B Antifungal activity |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2013.03.038 |
| 文献子类 | Article |
| 英文摘要 | Two new prenylated para-xylenes, named caulerprenylols A (1) and B (2), were isolated from the green alga Caulerpa racemosa, collected from the Zhanjiang coastline, China. The structures of the two metabolites were elucidated on the basis of detailed spectroscopic analysis. This is the first report of prenylated para-xylenes from marine algae and from marine organisms as well. Moreover, caulerprenylol B (2) is also characterized by an uncommon indane ring system. In in vitro bioassays, the new compounds exhibited a broad spectrum of antifungal activity against Candida glabrata (537), Trichophyton rubrum (Cmccftla), and Cryptococcus neoformans (32609) with MIC80 values between 4 and 64 mu g/mL when compared to amphotericin B (MIC80 values of 2.0, 1.0, and 4.0 mu g/mL, respectively) as a positive control and showed no growth inhibition activity against the tumor cells HL60 and A549. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS关键词 | MARINE-DERIVED FUNGUS ; DISEASED POTATO-TUBERS ; SESQUITERPENE ALCOHOL ; ASPERGILLUS SP ; PHYTOALEXINS ; RISHITINOL ; ALKALOIDS |
| 资助项目 | National Natural Science Foundation of China[20862013] ; National Natural Science Foundation of China[81001397] ; National Natural Science Foundation of China[21162016] ; Natural Science Foundation of Jiangxi Province, China[2010GQY0217] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000317333900003 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277642]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Mao, Shui-Chun |
| 作者单位 | 1.Chinese Acad Sci, Lushan 332900, Peoples R China; 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Nanchang Univ, Ctr Anal & Testing, Nanchang 330047, Peoples R China; 4.Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liu, Ai-Hong,Liu, Ding-Quan,Liang, Tong-Jun,et al. Caulerprenylols A and B, two rare antifungal prenylated para-xylenes from the green alga Caulerpa racemosa[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2013,23(9):2491-2494. |
| APA | Liu, Ai-Hong.,Liu, Ding-Quan.,Liang, Tong-Jun.,Yu, Xiao-Qing.,Feng, Mei-Tang.,...&Mao, Shui-Chun.(2013).Caulerprenylols A and B, two rare antifungal prenylated para-xylenes from the green alga Caulerpa racemosa.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,23(9),2491-2494. |
| MLA | Liu, Ai-Hong,et al."Caulerprenylols A and B, two rare antifungal prenylated para-xylenes from the green alga Caulerpa racemosa".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23.9(2013):2491-2494. |
入库方式： OAI收割
来源：上海药物研究所
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