Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2 '-oxindole] Derivatives
文献类型：期刊论文
| 作者 | Chen, Xianjie1,2; Chen, Hui1; Ji, Xun1; Jiang, Hualiang1,2 ; Yao, Zhu-Jun2; Liu, Hong1
|
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2013-04-19 |
| 卷号 | 15期号:8页码:1846-1849 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol4004542 |
| 文献子类 | Article |
| 英文摘要 | An asymmetric organo- and gold-catalyzed one-pot sequential Mannich/hydroamination reaction has been developed. Using this protocol, spiro[pyrrolidin-3,2'-oxindole] derivatives were synthesized in good yields (up to 91%) and excellent enantioselectivities (up to 97% ee). |
| WOS关键词 | MANNICH-TYPE REACTION ; ENANTIOSELECTIVE SYNTHESIS ; ALPHA,BETA-DIAMINO ACIDS ; AMINO-ACIDS ; THIOUREA ; HYDROAMINATION ; ALDIMINES ; CASCADE ; ALKYNES ; IMINES |
| 资助项目 | National Basic Research Program of China[2009CB940903] ; National Basic Research Program of China[2009CB918502] ; National Basic Research Program of China[2012CB518005] ; NSFC[21021063] ; NSFC[91229204] ; NSFC[81025017] ; National S&T Major Projects[2012ZX09103-101-072] ; China-EU Science and Technology Cooperation Project[1109] ; Silver Project[260644] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000318001400015 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277650]  |
| 专题 | 药物发现与设计中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物化学研究室 |
| 通讯作者 | Jiang, Hualiang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, State Key Lab Drug Res, Shanghai 200031, Peoples R China 2.Nanjing Univ, Sch Chem & Chem Engn, Nanjing Natl Lab Microstruct, Nanjing 210093, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Chen, Xianjie,Chen, Hui,Ji, Xun,et al. Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2 '-oxindole] Derivatives[J]. ORGANIC LETTERS,2013,15(8):1846-1849. |
| APA | Chen, Xianjie,Chen, Hui,Ji, Xun,Jiang, Hualiang,Yao, Zhu-Jun,&Liu, Hong.(2013).Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2 '-oxindole] Derivatives.ORGANIC LETTERS,15(8),1846-1849. |
| MLA | Chen, Xianjie,et al."Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2 '-oxindole] Derivatives".ORGANIC LETTERS 15.8(2013):1846-1849. |
入库方式： OAI收割
来源：上海药物研究所
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