Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors
文献类型：期刊论文
| 作者 | Zhang, Dengyou3; Ai, Jing1 ; Liang, Zhongjie4; Zhu, Wei3; Peng, Xia1; Chen, Xianjie3; Ji, YinChun1; Jiang, Hualiang2,3; Luo, Cheng3; Geng, Meiyu1
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2013-04-15 |
| 卷号 | 23期号:8页码:2408-2413 |
| 关键词 | c-Met EBC-1 cell Tyrosine kinase receptor |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2013.02.037 |
| 文献子类 | Article |
| 英文摘要 | A series of novel 5-(benzyloxy)pyridin-2(1H)-ones were designed, synthesized and biologically evaluated for c-Met inhibition. Various amides and benzoimidazoles at C-3 position were investigated. A potent compound 12b with a c-Met IC50 of 12 nM was identified. This compound exhibited potent inhibition of EBC-1 cell associated with c-Met constitutive activation and showed high selectivity for c-Met than other tested 11 kinases. The binding model 12b with c-Met was disclosed by docking analysis. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS关键词 | KINASE INHIBITORS ; DISCOVERY |
| 资助项目 | National Basic Research Program of China[2009CB940903] ; National Basic Research Program of China[2009 CB918502] ; National Basic Research Program of China[2012CB518005] ; National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[91229204] ; National Natural Science Foundation of China[81102461] ; National Natural Science Foundation of China[81025017] ; National S&T Major Projects[2012ZX09103-101-072] ; National S&T Major Projects[2012ZX09301001-007] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000316934000028 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277654]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物化学研究室 |
| 通讯作者 | Geng, Meiyu |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China; 2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res,CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 4.Soochow Univ, Ctr Syst Biol, Suzhou 215006, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Dengyou,Ai, Jing,Liang, Zhongjie,et al. Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2013,23(8):2408-2413. |
| APA | Zhang, Dengyou.,Ai, Jing.,Liang, Zhongjie.,Zhu, Wei.,Peng, Xia.,...&Liu, Hong.(2013).Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,23(8),2408-2413. |
| MLA | Zhang, Dengyou,et al."Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23.8(2013):2408-2413. |
入库方式： OAI收割
来源：上海药物研究所
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