Asymmetric Michael Addition of N-tert-Butanesulfinyl lmidate with alpha,beta-Unsaturated Diesters: Scope and Application to the Synthesis of Indanone Derivatives
文献类型：期刊论文
| 作者 | Wang, Jinfang; Zhou, Yu ; Zhang, Lei; Li, Zeng; Chen, Xianjie; Liu, Hong
|
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2013-04-05 |
| 卷号 | 15期号:7页码:1508-1511 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol400277h |
| 文献子类 | Article |
| 英文摘要 | An additive-free and highly diastereoselective Michael addition reaction of an N-tert-butanesulfinyl imidate to alpha,beta-unsaturated diesters has been developed using LDA as a base with good to excellent yields. The utility of this chemistry is further demonstrated by the asymmetric synthesis of 3-substituted indanone derivatives 8a, 8d, 8e, and 8i with high enantiomeric excess, which are potential building blocks for preparing biologically active lead compounds. |
| WOS关键词 | ANTI-1,3-AMINO ALCOHOLS ; SYN-1,3-AMINO ; ALDIMINES ; PTEROSINS ; IMINES ; ESTERS |
| 资助项目 | National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[91229204] ; National Natural Science Foundation of China[81102307] ; National Natural Science Foundation of China[81025017] ; National S&T Major Projects[2012ZX09103-101-072] ; China-EU Science and Technology Cooperation Project[1109] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000317327900023 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277658]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第一研究室 |
| 通讯作者 | Zhou, Yu |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jinfang,Zhou, Yu,Zhang, Lei,et al. Asymmetric Michael Addition of N-tert-Butanesulfinyl lmidate with alpha,beta-Unsaturated Diesters: Scope and Application to the Synthesis of Indanone Derivatives[J]. ORGANIC LETTERS,2013,15(7):1508-1511. |
| APA | Wang, Jinfang,Zhou, Yu,Zhang, Lei,Li, Zeng,Chen, Xianjie,&Liu, Hong.(2013).Asymmetric Michael Addition of N-tert-Butanesulfinyl lmidate with alpha,beta-Unsaturated Diesters: Scope and Application to the Synthesis of Indanone Derivatives.ORGANIC LETTERS,15(7),1508-1511. |
| MLA | Wang, Jinfang,et al."Asymmetric Michael Addition of N-tert-Butanesulfinyl lmidate with alpha,beta-Unsaturated Diesters: Scope and Application to the Synthesis of Indanone Derivatives".ORGANIC LETTERS 15.7(2013):1508-1511. |
入库方式： OAI收割
来源：上海药物研究所
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