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Efficient Total Synthesis of (S)-Dihydroresorcylide, a Bioactive Twelve-Membered Macrolide

文献类型：期刊论文

作者Zhang, Li2; Ma, Wenquan1; Xu, Lili1; Deng, Fei2; Guo, Yuewei2
刊名CHINESE JOURNAL OF CHEMISTRY
出版日期2013-03
卷号31期号:3页码:339-343
关键词dihydroresorcylide trans-resorcylide dimethyl ether ring-closing metathesis (RCM) carbonylation total synthesis
ISSN号1001-604X
DOI10.1002/cjoc.201300016
文献子类Article
英文摘要The efficient synthesis of (S)-dihydroresorcylide (1a) along with trans-resorcylide dimethyl ether (2b), was achieved in linear 9 steps from commercially available orcinol monohydrate (6) with esterification, carbonylation, and ring-closing metathesis (RCM) as the key steps in the synthetic sequence.
WOS关键词RING-CLOSING-METATHESIS ; TRANS-RESORCYLIDE ; CIS-RESORCYLIDE ; METABOLITES ; MACROCYCLES
资助项目Natural Science Foundation of China[21021063] ; Natural Science Foundation of China[81273430] ; National Marine "863" Project[2011AA09070102] ; National Marine "863" project[2013AA092902] ; SKLDR/SIMM Projects[SIMM1203ZZ-03]
WOS研究方向Chemistry
语种英语
CSCD记录号CSCD:4793361
WOS记录号WOS:000316809600007
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/277707]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Deng, Fei
作者单位1.Weifang Natl Hightech Ind Dev Zone, Weifang 261205, Shandong, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Zhang, Li,Ma, Wenquan,Xu, Lili,et al. Efficient Total Synthesis of (S)-Dihydroresorcylide, a Bioactive Twelve-Membered Macrolide[J]. CHINESE JOURNAL OF CHEMISTRY,2013,31(3):339-343.
APA Zhang, Li,Ma, Wenquan,Xu, Lili,Deng, Fei,&Guo, Yuewei.(2013).Efficient Total Synthesis of (S)-Dihydroresorcylide, a Bioactive Twelve-Membered Macrolide.CHINESE JOURNAL OF CHEMISTRY,31(3),339-343.
MLA Zhang, Li,et al."Efficient Total Synthesis of (S)-Dihydroresorcylide, a Bioactive Twelve-Membered Macrolide".CHINESE JOURNAL OF CHEMISTRY 31.3(2013):339-343.

入库方式： OAI收割

来源：上海药物研究所

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