Marine-Derived Angiogenesis Inhibitors for Cancer Therapy
文献类型:期刊论文
作者 | Wang, Ying-Qing![]() |
刊名 | MARINE DRUGS
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出版日期 | 2013-03 |
卷号 | 11期号:3页码:903-933 |
关键词 | marine natural products angiogenesis protein kinase cancer therapy |
ISSN号 | 1660-3397 |
DOI | 10.3390/md11030903 |
文献子类 | Review |
英文摘要 | Angiogenesis inhibitors have been successfully used for cancer therapy in the clinic. Many marine-derived natural products and their analogues have been reported to show antiangiogenic activities. Compared with the drugs in the clinic, these agents display interesting characteristics, including diverse sources, unique chemical structures, special modes of action, and distinct activity and toxicity profiles. This review will first provide an overview of the current marine-derived angiogenesis inhibitors based on their primary targets and/or mechanisms of action. Then, the marine-derived antiangiogenic protein kinase inhibitors will be focused on. And finally, the clinical trials of the marine-derived antiangiogenic agents will be discussed, with special emphasis on their application potentials, problems and possible coping strategies in their future development as anticancer drugs. |
WOS关键词 | PHASE-II TRIAL ; RENAL-CELL CARCINOMA ; HISTONE DEACETYLASE INHIBITOR ; VEIN ENDOTHELIAL-CELLS ; GYNECOLOGIC-ONCOLOGY-GROUP ; MOLECULAR-WEIGHT FUCOIDAN ; FIBROBLAST-GROWTH-FACTOR ; RELAPSED/REFRACTORY MULTIPLE-MYELOMA ; SEAWEED SARGASSUM-STENOPHYLLUM ; BRYOSTATIN-1 NSC NUMBER-339555 |
资助项目 | National Natural Science Foundation of China (NSFC)[81025020] ; National Natural Science Foundation of China (NSFC)[81021062] ; National Natural Science Foundation of China (NSFC)[81202548] ; National Basic Research Program of China[2012CB932502] ; National Science & Technology Major Project of China[2012ZX09301-001-002] ; "Interdisciplinary Cooperation Team" Program for Science and Technology Innovation of the Chinese Academy of Sciences[00000000] |
WOS研究方向 | Pharmacology & Pharmacy |
语种 | 英语 |
WOS记录号 | WOS:000316607800022 |
出版者 | MDPI |
源URL | [http://119.78.100.183/handle/2S10ELR8/277711] ![]() |
专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
通讯作者 | Miao, Ze-Hong |
作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Ying-Qing,Miao, Ze-Hong. Marine-Derived Angiogenesis Inhibitors for Cancer Therapy[J]. MARINE DRUGS,2013,11(3):903-933. |
APA | Wang, Ying-Qing,&Miao, Ze-Hong.(2013).Marine-Derived Angiogenesis Inhibitors for Cancer Therapy.MARINE DRUGS,11(3),903-933. |
MLA | Wang, Ying-Qing,et al."Marine-Derived Angiogenesis Inhibitors for Cancer Therapy".MARINE DRUGS 11.3(2013):903-933. |
入库方式: OAI收割
来源:上海药物研究所
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