中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Marine-Derived Angiogenesis Inhibitors for Cancer Therapy

文献类型:期刊论文

作者Wang, Ying-Qing; Miao, Ze-Hong
刊名MARINE DRUGS
出版日期2013-03
卷号11期号:3页码:903-933
关键词marine natural products angiogenesis protein kinase cancer therapy
ISSN号1660-3397
DOI10.3390/md11030903
文献子类Review
英文摘要Angiogenesis inhibitors have been successfully used for cancer therapy in the clinic. Many marine-derived natural products and their analogues have been reported to show antiangiogenic activities. Compared with the drugs in the clinic, these agents display interesting characteristics, including diverse sources, unique chemical structures, special modes of action, and distinct activity and toxicity profiles. This review will first provide an overview of the current marine-derived angiogenesis inhibitors based on their primary targets and/or mechanisms of action. Then, the marine-derived antiangiogenic protein kinase inhibitors will be focused on. And finally, the clinical trials of the marine-derived antiangiogenic agents will be discussed, with special emphasis on their application potentials, problems and possible coping strategies in their future development as anticancer drugs.
WOS关键词PHASE-II TRIAL ; RENAL-CELL CARCINOMA ; HISTONE DEACETYLASE INHIBITOR ; VEIN ENDOTHELIAL-CELLS ; GYNECOLOGIC-ONCOLOGY-GROUP ; MOLECULAR-WEIGHT FUCOIDAN ; FIBROBLAST-GROWTH-FACTOR ; RELAPSED/REFRACTORY MULTIPLE-MYELOMA ; SEAWEED SARGASSUM-STENOPHYLLUM ; BRYOSTATIN-1 NSC NUMBER-339555
资助项目National Natural Science Foundation of China (NSFC)[81025020] ; National Natural Science Foundation of China (NSFC)[81021062] ; National Natural Science Foundation of China (NSFC)[81202548] ; National Basic Research Program of China[2012CB932502] ; National Science & Technology Major Project of China[2012ZX09301-001-002] ; "Interdisciplinary Cooperation Team" Program for Science and Technology Innovation of the Chinese Academy of Sciences[00000000]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000316607800022
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/277711]  
专题药理学第一研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Miao, Ze-Hong
作者单位Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Wang, Ying-Qing,Miao, Ze-Hong. Marine-Derived Angiogenesis Inhibitors for Cancer Therapy[J]. MARINE DRUGS,2013,11(3):903-933.
APA Wang, Ying-Qing,&Miao, Ze-Hong.(2013).Marine-Derived Angiogenesis Inhibitors for Cancer Therapy.MARINE DRUGS,11(3),903-933.
MLA Wang, Ying-Qing,et al."Marine-Derived Angiogenesis Inhibitors for Cancer Therapy".MARINE DRUGS 11.3(2013):903-933.

入库方式: OAI收割

来源:上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。