Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault
文献类型：期刊论文
| 作者 | Liang, Lin-Fu2; Wang, Xu-Jie2; Zhang, Hai-Yan2 ; Liu, Hai-Li2; Li, Jia2; Lan, Le-Fu2; Zhang, Wen1; Guo, Yue-Wei2
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| 出版日期 | 2013-03-01 |
| 卷号 | 23期号:5页码:1334-1337 |
| ISSN号 | 0960-894X |
| 关键词 | Soft coral Sinularia depressa Steroid Neuroprotective Antibacterial PTP1B |
| DOI | 10.1016/j.bmcl.2012.12.087 |
| 文献子类 | Article |
| 英文摘要 | Two new steroids, (2 beta,3 beta,4 alpha,5 alpha,8 beta)-4-methylergost-24(28)-ene-2,3,8-triol (1) and (3 beta,7 alpha)-24-methyl-7-hydroperoxycholest- 5,24(28)-diene-3-ol (2), together with 13 known analogues (3-15) were isolated from the soft coral Sinularia depressa Tixier-Durivault. The structures of the new compounds were elucidated by detailed spectroscopic analysis and comparison with reported data. In the bioassay in vitro, compounds 3a, 4, and 14 exhibited potent PTP1B inhibitory activity, being similar as that of positive control oleanolic acid. Compound 14 also displayed a notable neuroprotective activity against both amyloid-beta(25-35)-and serum deprivation-induced injuries in SH-SY5Y cells while compound 11 showed a considerable antibacterial activity against Staphylococcus aureus. Preliminary structure-activity relationships of these steroids were discussed. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved. |
| WOS关键词 | MARINE-INVERTEBRATES ; LITOPHYTON-VIRIDIS ; METABOLITES ; NEPHTHEA |
| 资助项目 | Natural Science Foundation of China[21072204] ; Natural Science Foundation of China[21021063] ; Natural Science Foundation of China[81273430] ; National Marine '863' Project[2011AA-09070102] ; National Marine '863' Project[2013AA092902] ; SKLDR/SIMM Project[SIMM1203ZZ-03] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000314693400036 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277718]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第二研究室 药理学第三研究室 药物安全性评价中心 国家新药筛选中心 |
| 通讯作者 | Zhang, Wen |
| 作者单位 | 1.Second Mil Med Univ, Sch Pharm, Res Ctr Marine Drugs, Shanghai 200433, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liang, Lin-Fu,Wang, Xu-Jie,Zhang, Hai-Yan,et al. Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2013,23(5):1334-1337. |
| APA | Liang, Lin-Fu.,Wang, Xu-Jie.,Zhang, Hai-Yan.,Liu, Hai-Li.,Li, Jia.,...&Guo, Yue-Wei.(2013).Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,23(5),1334-1337. |
| MLA | Liang, Lin-Fu,et al."Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23.5(2013):1334-1337. |
入库方式： OAI收割
来源：上海药物研究所
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