Targeting Epigenetics in Nervous System Disease
文献类型：期刊论文
| 作者 | Zhang, Ruihan; Lu, Junyan; Kong, Xiangqian; Jin, Lu; Luo, Cheng
|
| 刊名 | CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
 |
| 出版日期 | 2013-02 |
| 卷号 | 12期号:1页码:126-141 |
| ISSN号 | 1871-5273 |
| 关键词 | DNA methyltransferase epigenetics glioma histone deacetylase histone methyltransferase nervous system disease neurodevelopmental disease neurodegenerative disease |
| DOI | 10.2174/1871527311312010018 |
| 文献子类 | Article |
| 英文摘要 | Epigenetics is key to understanding modulation of gene expression at specific stages and conditions in nervous system development and function. In epigenetic processes, a variety of enzymes contribute to modify chromatin with methyl, acetyl or other chemical marks, leading to repression or activation of the targeted gene without altering the original sequence. Aberrant activities of these epigenetic enzymes are implicated in many nervous system diseases, including neurodevelopmental disorders, brain cancer, neurodegenerative diseases, and mental illnesses. Thus, they have emerged as new targets for treating a variety of nervous system disorders. In this review, we briefly summarize the association between various epigenetic mechanisms and discuss recent progress in drug discovery efforts involving epigenetic regulators. |
| WOS关键词 | HISTONE DEACETYLASE INHIBITORS ; AMYOTROPHIC-LATERAL-SCLEROSIS ; PLURIPOTENT STEM-CELLS ; SUBEROYLANILIDE HYDROXAMIC ACID ; PROTECTS DOPAMINERGIC-NEURONS ; RUBINSTEIN-TAYBI-SYNDROME ; MIXED-LINEAGE LEUKEMIA ; CREB-BINDING PROTEIN ; FRAGILE-X-SYNDROME ; PHASE-II TRIAL |
| 资助项目 | National Natural Science Foundation of China[20972174] ; National Natural Science Foundation of China[91029704] ; Hi-Tech Research and Development Program of China[2012AA020302] ; State Key Program of Basic Research of China[2009CB918502] ; Chinese Academy of Sciences[XDA01040305] |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| WOS记录号 | WOS:000315996300018 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277737]  |
| 专题 | 药物发现与设计中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Luo, Cheng |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ruihan,Lu, Junyan,Kong, Xiangqian,et al. Targeting Epigenetics in Nervous System Disease[J]. CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS,2013,12(1):126-141. |
| APA | Zhang, Ruihan,Lu, Junyan,Kong, Xiangqian,Jin, Lu,&Luo, Cheng.(2013).Targeting Epigenetics in Nervous System Disease.CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS,12(1),126-141. |
| MLA | Zhang, Ruihan,et al."Targeting Epigenetics in Nervous System Disease".CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS 12.1(2013):126-141. |
入库方式： OAI收割
来源：上海药物研究所
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