Copper-Assisted/Copper-Free Synthesis of Functionalized Dibenzo[b,f]oxepins and Their Analogs via a One-Pot Tandem Reaction
文献类型：期刊论文
| 作者 | Wang, Yuqin; Chen, Yanhong; He, Qian ; Xie, Yuyuan; Yang, Chunhao
|
| 刊名 | HELVETICA CHIMICA ACTA
 |
| 出版日期 | 2013-02 |
| 卷号 | 96期号:2页码:296-308 |
| ISSN号 | 0018-019X |
| DOI | 10.1002/hlca.201200116 |
| 文献子类 | Article |
| 英文摘要 | A simple, convenient, and efficient method for the formation of functionalized dibenzo[b,f]oxepins and their analogs bearing both electron-donating and electron-withdrawing groups has been developed via a one-pot cascade reaction. Most starting materials are commercially available 2-(2-hydroxyphenyl)-acetonitriles and 2-haloarylaldehydes. The procedure makes use of Cs2CO3 as the base, and DMF as solvent under copper-assisted/copper-free conditions. The reaction has a comprehensive group tolerance for substrates. Most of the reactions were complete within 1 h in good-to-excellent yields, and the reaction temperatures were relatively low. The protocol could be scaled up to grams without lowering the yield. A reaction mechanism was also proposed. |
| WOS关键词 | DERIVATIVES ; AGENTS ; IDENTIFICATION ; REARRANGEMENT |
| 资助项目 | Chinese Academy of Sciences, the National Natural Science Foundation of China[21072205] ; Chinese Academy of Sciences, the National Natural Science Foundation of China[SIMM1203ZZ-0103] ; Chinese Academy of Sciences, the National Natural Science Foundation of China[SIMM1105KF-02] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000316274600013 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277739]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Chunhao |
| 作者单位 | Chinese Acad Sci, SIBS, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yuqin,Chen, Yanhong,He, Qian,et al. Copper-Assisted/Copper-Free Synthesis of Functionalized Dibenzo[b,f]oxepins and Their Analogs via a One-Pot Tandem Reaction[J]. HELVETICA CHIMICA ACTA,2013,96(2):296-308. |
| APA | Wang, Yuqin,Chen, Yanhong,He, Qian,Xie, Yuyuan,&Yang, Chunhao.(2013).Copper-Assisted/Copper-Free Synthesis of Functionalized Dibenzo[b,f]oxepins and Their Analogs via a One-Pot Tandem Reaction.HELVETICA CHIMICA ACTA,96(2),296-308. |
| MLA | Wang, Yuqin,et al."Copper-Assisted/Copper-Free Synthesis of Functionalized Dibenzo[b,f]oxepins and Their Analogs via a One-Pot Tandem Reaction".HELVETICA CHIMICA ACTA 96.2(2013):296-308. |
入库方式： OAI收割
来源：上海药物研究所
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