Cytotoxic sesquiterpenoids from Sarcandra glabra
文献类型：期刊论文
| 作者 | Ni, Gang; Zhang, Hua; Liu, Hong-Chun ; Yang, Sheng-Ping; Geng, Mei-Yu; Yue, Jian-Min
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2013-01-14 |
| 卷号 | 69期号:2页码:564-569 |
| 关键词 | Sarcandra glabra Sarcandrolides F-J Sarcandralactones C-E Sesquiterpenoid dimers CD exciton chirality Structural elucidation |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2012.11.023 |
| 文献子类 | Article |
| 英文摘要 | Five new sesquiterpenoid dimers, sarcandrolides F-J (1-5), three new sesquiterpenoid monomers (6-8), and 14 known sesquiterpenoids, were isolated from the whole plants of Sarcandra glabra. The absolute configurations of compounds 1-5 were established by the CD exciton chirality method. Compound 1 represents the first example of a lindenane-type sesquiterpenoid dimer bearing a hydroperoxy group at C-5. Compounds 1 and 3 exhibited cytotoxicity against the HL-60 cell line with IC50 values of 0.03 and 1.2 mu M, respectively. (c) 2012 Elsevier Ltd. All rights reserved. |
| WOS关键词 | CHLORANTHUS-JAPONICUS ; CHEMICAL-CONSTITUENTS ; DIMERIC SESQUITERPENOIDS ; C-F ; PLANTS ; HOLOSTEGIUS ; SPICATUS ; SERRATUS ; BLOCKERS ; POTENT |
| 资助项目 | National Natural Science Foundation[81021062] ; National Natural Science Foundation[20902095] ; Foundation from the Ministry of Science and Technology of the People's Republic of China[2012CB721105] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000314371800018 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277768]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ni, Gang,Zhang, Hua,Liu, Hong-Chun,et al. Cytotoxic sesquiterpenoids from Sarcandra glabra[J]. TETRAHEDRON,2013,69(2):564-569. |
| APA | Ni, Gang,Zhang, Hua,Liu, Hong-Chun,Yang, Sheng-Ping,Geng, Mei-Yu,&Yue, Jian-Min.(2013).Cytotoxic sesquiterpenoids from Sarcandra glabra.TETRAHEDRON,69(2),564-569. |
| MLA | Ni, Gang,et al."Cytotoxic sesquiterpenoids from Sarcandra glabra".TETRAHEDRON 69.2(2013):564-569. |
入库方式： OAI收割
来源：上海药物研究所
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