Highly diastereoselective synthesis of 3-indolylglycines via an asymmetric oxidative heterocoupling reaction of a chiral nickel(II) complex and indoles
文献类型：期刊论文
| 作者 | Lin, Daizong1; Wang, Jiang1 ; Zhang, Xu1,2; Zhou, Shengbin1; Lian, Jie1,2; Jiang, Hualiang1; Liu, Hong1,2
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| 刊名 | CHEMICAL COMMUNICATIONS
 |
| 出版日期 | 2013 |
| 卷号 | 49期号:25页码:2575-2577 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/c3cc38908a |
| 文献子类 | Article |
| 英文摘要 | The asymmetric synthesis of 3-indolylglycine derivatives was achieved by an oxidative heterocoupling reaction. This method for the selective C-3 functionalization of unprotected indoles with the chiral equivalent of a nucleophilic glycine nickel(II) complex afforded adducts with high diastereoselectivities. The decomposition of adducts readily afforded 3-indolylglycine derivatives in high yields. |
| WOS关键词 | ALPHA-AMINO-ACIDS ; SUBSTITUTED PYROGLUTAMIC ACIDS ; MICHAEL ADDITION-REACTIONS ; 1ST TOTAL-SYNTHESIS ; ENANTIOSELECTIVE SYNTHESIS ; NUCLEOPHILIC GLYCINE ; ALDOL REACTIONS ; CARBONYL-COMPOUNDS ; ROOM-TEMPERATURE ; NI(II) COMPLEX |
| 资助项目 | National Basic Research Program of China[2009CB940903] ; National Basic Research Program of China[2009CB918502] ; National Basic Research Program of China[2012CB518005] ; National Natural Science Foundation of China[20721003] ; National Natural Science Foundation of China[91229204] ; National Natural Science Foundation of China[81025017] ; National S&T Major Projects[2012ZX09103-101-072] ; China-EU Science and Technology Cooperation Project[1109] ; Silver Project[260644] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000315465000030 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277806]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Daizong,Wang, Jiang,Zhang, Xu,et al. Highly diastereoselective synthesis of 3-indolylglycines via an asymmetric oxidative heterocoupling reaction of a chiral nickel(II) complex and indoles[J]. CHEMICAL COMMUNICATIONS,2013,49(25):2575-2577. |
| APA | Lin, Daizong.,Wang, Jiang.,Zhang, Xu.,Zhou, Shengbin.,Lian, Jie.,...&Liu, Hong.(2013).Highly diastereoselective synthesis of 3-indolylglycines via an asymmetric oxidative heterocoupling reaction of a chiral nickel(II) complex and indoles.CHEMICAL COMMUNICATIONS,49(25),2575-2577. |
| MLA | Lin, Daizong,et al."Highly diastereoselective synthesis of 3-indolylglycines via an asymmetric oxidative heterocoupling reaction of a chiral nickel(II) complex and indoles".CHEMICAL COMMUNICATIONS 49.25(2013):2575-2577. |
入库方式： OAI收割
来源：上海药物研究所
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