Gold-catalyzed Michael addition/intramolecular annulation cascade: an effective pathway for the chemoselective- and regioselective synthesis of tetracyclic indole derivatives in water
文献类型：期刊论文
| 作者 | Xu, Shengtao1,2; Zhou, Yu1 ; Xu, Jinyi2; Jiang, Hualiang1; Liu, Hong1,2
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| 刊名 | GREEN CHEMISTRY
 |
| 出版日期 | 2013 |
| 卷号 | 15期号:3页码:718-726 |
| ISSN号 | 1463-9262 |
| DOI | 10.1039/c2gc36301a |
| 文献子类 | Article |
| 英文摘要 | The report describes a gold(I) complex and trifluoroacetic acid (TFA) cocatalyzed one-pot, Michael addition/intramolecular cyclization cascade reaction for the synthesis of unusual tetracyclic indoles containing a seven-membered ring in water with microwave irradiation (MW). This protocol presents an operationally simple, rapid and environmentally friendly strategy for preparing potential biologically interesting fused-indole molecular architectures from some simple starting materials. |
| WOS关键词 | ELECTROPHILIC SUBSTITUTION ; 3-SUBSTITUTED INDOLES ; GREEN CHEMISTRY ; AQUEOUS-MEDIA ; ALKYLATION ; ARYLATION ; SOLVENT ; FOCUS ; BOND |
| 资助项目 | National Basic Research Program of China[2009CB940903] ; National Basic Research Program of China[2012CB518005] ; National Natural Science Foundation of China[81102307] ; National Natural Science Foundation of China[81025017] ; National S&T Major Projects[2012ZX09103-101-072] ; China-EU Science and Technology Cooperation Project[1109] ; Silver Project[260644] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000315356400022 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277808]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xu, Shengtao |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Ctr Drug Discovery & Design, Shanghai 201203, Peoples R China 2.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xu, Shengtao,Zhou, Yu,Xu, Jinyi,et al. Gold-catalyzed Michael addition/intramolecular annulation cascade: an effective pathway for the chemoselective- and regioselective synthesis of tetracyclic indole derivatives in water[J]. GREEN CHEMISTRY,2013,15(3):718-726. |
| APA | Xu, Shengtao,Zhou, Yu,Xu, Jinyi,Jiang, Hualiang,&Liu, Hong.(2013).Gold-catalyzed Michael addition/intramolecular annulation cascade: an effective pathway for the chemoselective- and regioselective synthesis of tetracyclic indole derivatives in water.GREEN CHEMISTRY,15(3),718-726. |
| MLA | Xu, Shengtao,et al."Gold-catalyzed Michael addition/intramolecular annulation cascade: an effective pathway for the chemoselective- and regioselective synthesis of tetracyclic indole derivatives in water".GREEN CHEMISTRY 15.3(2013):718-726. |
入库方式： OAI收割
来源：上海药物研究所
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