Efficient Synthesis of a (Z)-3-Methyleneisoindolin-1-one Library Using Cu(OAc)(2)center dot H2O/DBU under Microwave Irradiation
文献类型：期刊论文
| 作者 | Zhang, Li2; Zhang, Yongliang1; Wang, Xin1 ; Shen, Jingkang1
|
| 刊名 | MOLECULES
 |
| 出版日期 | 2013-01 |
| 卷号 | 18期号:1页码:654-665 |
| 关键词 | (Z)-3-methyleneisoindolin-1-one Cu(OAc)(2)center dot H2O/DBU domino reaction cross coupling microwave irradiation |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules18010654 |
| 文献子类 | Article |
| 英文摘要 | Microwave-promoted efficient synthesis of a (Z)-3-methyleneisoindolin-1-one library from 2-bromobenzamides and terminal alkynes using Cu(OAc)(2)center dot H2O/DBU is described. Various benzamide substituents, ring substitutions, including heteroaryl, aryl acetylenes and aliphatic alkynes, could be applied to afford the desired products in good to moderate yield with high stereoselectivity. It is noteworthy that DBU maybe play a dual role as not only the base, but also as a ligand for copper. The reaction is catalyzed by the complex of Cu(OAc)(2)center dot H2O and DBU without other additives. |
| WOS关键词 | FRIEDEL-CRAFTS REACTIONS ; MIYAURA DOMINO REACTIONS ; STEREOSELECTIVE-SYNTHESIS ; TERMINAL ALKYNES ; (Z)-3-ARYL(ALKYL)IDENE ISOINDOLIN-1-ONES ; SUBSTITUTED 3-METHYLENEISOINDOLIN-1-ONES ; HIGHLY REGIO ; PALLADIUM ; LENNOXAMINE ; CYCLIZATION |
| 资助项目 | Natural Science Foundation of China[81102395] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000314032900040 |
| 出版者 | MDPI AG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277823]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Li |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China 2.Shanghai Jiao Tong Univ, Instrumental Anal Ctr, Shanghai 200240, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Li,Zhang, Yongliang,Wang, Xin,et al. Efficient Synthesis of a (Z)-3-Methyleneisoindolin-1-one Library Using Cu(OAc)(2)center dot H2O/DBU under Microwave Irradiation[J]. MOLECULES,2013,18(1):654-665. |
| APA | Zhang, Li,Zhang, Yongliang,Wang, Xin,&Shen, Jingkang.(2013).Efficient Synthesis of a (Z)-3-Methyleneisoindolin-1-one Library Using Cu(OAc)(2)center dot H2O/DBU under Microwave Irradiation.MOLECULES,18(1),654-665. |
| MLA | Zhang, Li,et al."Efficient Synthesis of a (Z)-3-Methyleneisoindolin-1-one Library Using Cu(OAc)(2)center dot H2O/DBU under Microwave Irradiation".MOLECULES 18.1(2013):654-665. |
入库方式： OAI收割
来源：上海药物研究所
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