Three-Component, One-Pot Sequential Synthesis of Functionalized Cyclazines: 3H-1,2a(1),3-Triazaacenaphthylenes
文献类型：期刊论文
| 作者 | Sun, Hongpeng2,3; Zhou, Huayong2; Khorev, Oleg1; Jiang, Ruwei2; Yu, Ting; Wang, Xin2 ; Du, Yongli3; Ma, Yi3; Meng, Tao2; Shen, Jingkang2
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2012-12-07 |
| 卷号 | 77期号:23页码:10745-10751 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/jo3021105 |
| 文献子类 | Article |
| 英文摘要 | An efficient tandem route to the synthesis of 3H-1,2a(1),3-triazaacenaphthylene derivatives of the cyclazine family has been developed. Target compounds were obtained in moderate to good yields by a Yb(OTf)(3)/Ag2CO3-catalyzed, three-component domino reaction. This in turn will set the stage for a wide application of this useful reaction for the synthesis of structurally diverse polyheterocyclic skeletons containing the imidazo[1,2-a]pyridine privileged structure. |
| WOS关键词 | BRIDGEHEAD NITROGEN-ATOMS ; MULTICOMPONENT REACTIONS ; COMBINATORIAL SYNTHESIS ; HETEROCYCLIC-COMPOUNDS ; MOLECULAR COMPLEXITY ; DERIVATIVES ; ISOCYANIDES ; CHEMISTRY ; STRATEGIES ; SCAFFOLDS |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2012ZX09103-101-026] ; National Natural Science Foundation of China[81001355] ; National Natural Science Foundation of China[81273367] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000311926100029 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277849]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Meng, Tao |
| 作者单位 | 1.Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Shandong Polytech Univ, Sch Chem & Pharmaceut Engn, Jinan 250353, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Sun, Hongpeng,Zhou, Huayong,Khorev, Oleg,et al. Three-Component, One-Pot Sequential Synthesis of Functionalized Cyclazines: 3H-1,2a(1),3-Triazaacenaphthylenes[J]. JOURNAL OF ORGANIC CHEMISTRY,2012,77(23):10745-10751. |
| APA | Sun, Hongpeng.,Zhou, Huayong.,Khorev, Oleg.,Jiang, Ruwei.,Yu, Ting.,...&Shen, Jingkang.(2012).Three-Component, One-Pot Sequential Synthesis of Functionalized Cyclazines: 3H-1,2a(1),3-Triazaacenaphthylenes.JOURNAL OF ORGANIC CHEMISTRY,77(23),10745-10751. |
| MLA | Sun, Hongpeng,et al."Three-Component, One-Pot Sequential Synthesis of Functionalized Cyclazines: 3H-1,2a(1),3-Triazaacenaphthylenes".JOURNAL OF ORGANIC CHEMISTRY 77.23(2012):10745-10751. |
入库方式： OAI收割
来源：上海药物研究所
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