中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Enhanced Dissolution and Stability of Lansoprazole by Cyclodextrin Inclusion Complexation: Preparation, Characterization, and Molecular Modeling

文献类型:期刊论文

作者Lu, Yi1,2; Guo, Tao3; Qi, Jianping1,2; Zhang, Jiwen3,4; Wu, Wei1,2
刊名AAPS PHARMSCITECH
出版日期2012-12
卷号13期号:4页码:1222-1229
关键词cyclodextrin dissolution inclusion complex lansoprazole molecular modeling stability
ISSN号1530-9932
DOI10.1208/s12249-012-9842-z
文献子类Article
英文摘要In this study, lansoprazole (LSP)/cyclodextrin (CD) inclusion complexes were prepared using a fluid bed coating technique, with beta-cyclodextrin (beta-CD) and 2-hydroxypropyl-beta-cyclodextrin (HPCD) as the host molecules, respectively, to simultaneously improve the dissolution and stability of LSP. The dissolution rate and stability of LSP was dramatically enhanced by inclusion complexation regardless of CD type. LSP/HPCD inclusion complex was more stable under illumination than LSP/beta-CD inclusion complex. Differential scanning calorimetry and powder X-ray diffractometry proved the absence of crystallinity in both LSP/CD inclusion complexes. Fourier transform infrared spectroscopy together with molecular modeling indicated that the benzimidazole of LSP was included in the cavity of both CDs, while LSP was more deeply included in HPCDthan beta-CD. The enhanced photostability was due to the inclusion of the sulfinyl moiety into the HPCD cavity. CD inclusion complexation could improve the dissolution and stability of LSP.
WOS关键词BED COATING TECHNIQUE ; BETA-CYCLODEXTRIN ; PHARMACEUTICAL APPLICATIONS ; PHASE SOLUBILITY ; SOLID-STATE ; IN-VITRO ; OMEPRAZOLE ; PHARMACOKINETICS ; METHODOLOGY ; EFFICACY
资助项目Shanghai Commission of Education[10SG05] ; Shanghai Commission of Science and Technology[10430709200] ; International Science and Technology Cooperation Project[S2010GR0920] ; Key National Science & Technology Projects[2010ZX09401-402]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000313500500021
出版者SPRINGER
源URL[http://119.78.100.183/handle/2S10ELR8/277851]  
专题药物制剂研究中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Zhang, Jiwen
作者单位1.Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China;
2.Fudan Univ, PLA, Shanghai 201203, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
4.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Lu, Yi,Guo, Tao,Qi, Jianping,et al. Enhanced Dissolution and Stability of Lansoprazole by Cyclodextrin Inclusion Complexation: Preparation, Characterization, and Molecular Modeling[J]. AAPS PHARMSCITECH,2012,13(4):1222-1229.
APA Lu, Yi,Guo, Tao,Qi, Jianping,Zhang, Jiwen,&Wu, Wei.(2012).Enhanced Dissolution and Stability of Lansoprazole by Cyclodextrin Inclusion Complexation: Preparation, Characterization, and Molecular Modeling.AAPS PHARMSCITECH,13(4),1222-1229.
MLA Lu, Yi,et al."Enhanced Dissolution and Stability of Lansoprazole by Cyclodextrin Inclusion Complexation: Preparation, Characterization, and Molecular Modeling".AAPS PHARMSCITECH 13.4(2012):1222-1229.

入库方式: OAI收割

来源:上海药物研究所

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