Enhanced Dissolution and Stability of Lansoprazole by Cyclodextrin Inclusion Complexation: Preparation, Characterization, and Molecular Modeling
文献类型：期刊论文
| 作者 | Lu, Yi1,2; Guo, Tao3; Qi, Jianping1,2; Zhang, Jiwen3,4 ; Wu, Wei1,2
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| 刊名 | AAPS PHARMSCITECH
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| 出版日期 | 2012-12 |
| 卷号 | 13期号:4页码:1222-1229 |
| 关键词 | cyclodextrin dissolution inclusion complex lansoprazole molecular modeling stability |
| ISSN号 | 1530-9932 |
| DOI | 10.1208/s12249-012-9842-z |
| 文献子类 | Article |
| 英文摘要 | In this study, lansoprazole (LSP)/cyclodextrin (CD) inclusion complexes were prepared using a fluid bed coating technique, with beta-cyclodextrin (beta-CD) and 2-hydroxypropyl-beta-cyclodextrin (HPCD) as the host molecules, respectively, to simultaneously improve the dissolution and stability of LSP. The dissolution rate and stability of LSP was dramatically enhanced by inclusion complexation regardless of CD type. LSP/HPCD inclusion complex was more stable under illumination than LSP/beta-CD inclusion complex. Differential scanning calorimetry and powder X-ray diffractometry proved the absence of crystallinity in both LSP/CD inclusion complexes. Fourier transform infrared spectroscopy together with molecular modeling indicated that the benzimidazole of LSP was included in the cavity of both CDs, while LSP was more deeply included in HPCDthan beta-CD. The enhanced photostability was due to the inclusion of the sulfinyl moiety into the HPCD cavity. CD inclusion complexation could improve the dissolution and stability of LSP. |
| WOS关键词 | BED COATING TECHNIQUE ; BETA-CYCLODEXTRIN ; PHARMACEUTICAL APPLICATIONS ; PHASE SOLUBILITY ; SOLID-STATE ; IN-VITRO ; OMEPRAZOLE ; PHARMACOKINETICS ; METHODOLOGY ; EFFICACY |
| 资助项目 | Shanghai Commission of Education[10SG05] ; Shanghai Commission of Science and Technology[10430709200] ; International Science and Technology Cooperation Project[S2010GR0920] ; Key National Science & Technology Projects[2010ZX09401-402] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000313500500021 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277851]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Jiwen |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China; 2.Fudan Univ, PLA, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Yi,Guo, Tao,Qi, Jianping,et al. Enhanced Dissolution and Stability of Lansoprazole by Cyclodextrin Inclusion Complexation: Preparation, Characterization, and Molecular Modeling[J]. AAPS PHARMSCITECH,2012,13(4):1222-1229. |
| APA | Lu, Yi,Guo, Tao,Qi, Jianping,Zhang, Jiwen,&Wu, Wei.(2012).Enhanced Dissolution and Stability of Lansoprazole by Cyclodextrin Inclusion Complexation: Preparation, Characterization, and Molecular Modeling.AAPS PHARMSCITECH,13(4),1222-1229. |
| MLA | Lu, Yi,et al."Enhanced Dissolution and Stability of Lansoprazole by Cyclodextrin Inclusion Complexation: Preparation, Characterization, and Molecular Modeling".AAPS PHARMSCITECH 13.4(2012):1222-1229. |
入库方式： OAI收割
来源：上海药物研究所
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