Microwave-Assisted One-Step Synthesis of Acetophenones via Palladium-Catalyzed Regioselective Arylation of Vinyloxytrimethylsilane
文献类型：期刊论文
| 作者 | Qian, Wangke1,2; Zhang, Lei1; Sun, Haifeng2; Jiang, Hualiang1 ; Liu, Hong1
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| 刊名 | ADVANCED SYNTHESIS & CATALYSIS
 |
| 出版日期 | 2012-11 |
| 卷号 | 354期号:17页码:3231-3236 |
| 关键词 | acetophenones acylation reagents Heck arylation palladium regioselectivity |
| ISSN号 | 1615-4150 |
| DOI | 10.1002/adsc.201200334 |
| 文献子类 | Article |
| 英文摘要 | The regiochemistry of the palladium-mediated arylation (Heck arylation) of enol ethers is sensitive to the structure of the enol ether, the arylating agent and the catalytic system. In this study, an effective and practical method was successfully developed for the synthesis of acetophenones with high regioselectivity under palladium-catalyzed conditions. A variety of acetophenones was readily prepared from aryl iodides in good to excellent yields under microwave irradiation in a single step. The key feature of our new protocol is the use of vinyloxytrimethylsilane as a highly regioselective acylation reagent. |
| WOS关键词 | ELECTRON-RICH OLEFINS ; SUPERCRITICAL CARBON-DIOXIDE ; CROSS-COUPLING REACTION ; ENOL ETHERS ; MOLECULAR-OXYGEN ; ACYL CHLORIDES ; ARYL BROMIDES ; HECK REACTION ; VINYL ETHERS ; COBALT(II) PORPHYRIN |
| 资助项目 | National Basic Research Program of China[2009CB940903] ; National Basic Research Program of China[2012CB518000] ; National Natural Science Foundation of China[20721003] ; National Natural Science Foundation of China[20872153] ; National Natural Science Foundation of China[81025017] ; National S&T Major Projects[2012ZX09103-101-072] ; Silver Project[260644] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000311296300012 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277881]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China; 2.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qian, Wangke,Zhang, Lei,Sun, Haifeng,et al. Microwave-Assisted One-Step Synthesis of Acetophenones via Palladium-Catalyzed Regioselective Arylation of Vinyloxytrimethylsilane[J]. ADVANCED SYNTHESIS & CATALYSIS,2012,354(17):3231-3236. |
| APA | Qian, Wangke,Zhang, Lei,Sun, Haifeng,Jiang, Hualiang,&Liu, Hong.(2012).Microwave-Assisted One-Step Synthesis of Acetophenones via Palladium-Catalyzed Regioselective Arylation of Vinyloxytrimethylsilane.ADVANCED SYNTHESIS & CATALYSIS,354(17),3231-3236. |
| MLA | Qian, Wangke,et al."Microwave-Assisted One-Step Synthesis of Acetophenones via Palladium-Catalyzed Regioselective Arylation of Vinyloxytrimethylsilane".ADVANCED SYNTHESIS & CATALYSIS 354.17(2012):3231-3236. |
入库方式： OAI收割
来源：上海药物研究所
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