Atomic force microscopy imaging and mechanical properties measurement of red blood cells and aggressive cancer cells
文献类型：期刊论文
| 作者 | Li Mi2,3,5; Liu LianQing2; Xi Ning2,4; Wang YueChao2; Dong ZaiLi2; Xiao XiuBin1; Zhang WeiJing1 |
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2012-11 |
| 卷号 | 55期号:11页码:968-973 |
| 关键词 | atomic force microscopy red blood cell cancer cell mechanical properties Young's modulus |
| ISSN号 | 1674-7305 |
| DOI | 10.1007/s11427-012-4399-3 |
| 文献子类 | Article |
| 英文摘要 | Mechanical properties play an important role in regulating cellular activities and are critical for unlocking the mysteries of life. Atomic force microscopy (AFM) enables researchers to measure mechanical properties of single living cells under physiological conditions. Here, AFM was used to investigate the topography and mechanical properties of red blood cells (RBCs) and three types of aggressive cancer cells (Burkitt's lymphoma Raji, cutaneous lymphoma Hut, and chronic myeloid leukemia K562). The surface topography of the RBCs and the three cancer cells was mapped with a conventional AFM probe, while mechanical properties were investigated with a micro-sphere glued onto a tip-less cantilever. The diameters of RBCs are significantly smaller than those of the cancer cells, and mechanical measurements indicated that Young's modulus of RBCs is smaller than those of the cancer cells. Aggressive cancer cells have a lower Young's modulus than that of indolent cancer cells, which may improve our understanding of metastasis. |
| WOS关键词 | LYMPHOMA ; BIOMECHANICS ; CYTOSKELETON ; ELASTICITY ; ADHESION |
| 资助项目 | National Natural Science Foundation of China[60904095] ; National Natural Science Foundation of China[61175103] ; CAS FEA International Partnership Program for Creative Research Teams[00000000] ; State Key Laboratory of Drug Research[00000000] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000311398500005 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277889]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Liu LianQing |
| 作者单位 | 1.Acad Mil Med Sci, Affiliated Hosp, Dept Lymphoma, Beijing 100071, Peoples R China; 2.Chinese Acad Sci, Shenyang Inst Automat, State Key Lab Robot, Shenyang 110016, Peoples R China; 3.Univ Beijing, Chinese Acad Sci, Beijing 100049, Peoples R China; 4.City Univ Hong Kong, Dept Mech & Biomed Engn, Hong Kong, Hong Kong, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Mi,Liu LianQing,Xi Ning,et al. Atomic force microscopy imaging and mechanical properties measurement of red blood cells and aggressive cancer cells[J]. SCIENCE CHINA-LIFE SCIENCES,2012,55(11):968-973. |
| APA | Li Mi.,Liu LianQing.,Xi Ning.,Wang YueChao.,Dong ZaiLi.,...&Zhang WeiJing.(2012).Atomic force microscopy imaging and mechanical properties measurement of red blood cells and aggressive cancer cells.SCIENCE CHINA-LIFE SCIENCES,55(11),968-973. |
| MLA | Li Mi,et al."Atomic force microscopy imaging and mechanical properties measurement of red blood cells and aggressive cancer cells".SCIENCE CHINA-LIFE SCIENCES 55.11(2012):968-973. |
入库方式： OAI收割
来源：上海药物研究所
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