New Azaphilones and Chlorinated Phenolic Glycosides from Chaetomium elatum with Caspase-3 Inhibitory Activity
文献类型：期刊论文
| 作者 | Chen, Guo-Dong2,5; Li, Yan-Jun2; Gao, Hao2; Chen, Ying2; Li, Xiao-Xia2; Li, Jia3,4 ; Guo, Liang-Dong1; Cen, Ying-Zhou5; Yao, Xin-Sheng2
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| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2012-10 |
| 卷号 | 78期号:15页码:1683-1689 |
| 关键词 | Chaetomium elatum Chaetomiaceae azaphilones chlorinated phenolic glycosides caspase-3 inhibitors |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/s-0032-1315211 |
| 文献子类 | Article |
| 英文摘要 | Three new azaphilones, chaetomugilin S (1), 7,5'-bis-epi-chaetoviridin A (2), and 7-epi-chaetoviridin E (3), and two new chlorinated phenolic glycosides, globosumoside A (4) and globosumoside B (5), were isolated from the crude extract of the fungal strain Chaetomium elatum No. 89-1-3-1. Their structures were determined by detailed NMR and MS spectroscopic analyses. The absolute configurations of C-7 in chaetomugilin S (1), 7,5'-bis-epi-chaetoviridin A (2), and 7-epi-chaetoviridin E (3) were assigned by CD experiments, and the absolute configurations of 1 and 2 were established by X-ray crystallography. Compounds 1-3 are the first examples of 7R-configurated azaphilones with a chlorinated isochromen from Chaetomium spp. In addition, compounds 1-3 showed inhibitory activity in the cysteine aspartyl-specific protease-3 (caspase-3) enzymatic assay, with IC50 values of 20.6, 10.9, and 7.9 mu M, respectively. |
| WOS关键词 | APOPTOSIS ; GLOBOSUM |
| 资助项目 | Ministry of Science and Technology of China[2009CB522300] ; Ministry of Science and Technology of China[2009ZX09302-004] ; program for New Century Excellent Talents in University from the Ministry of Education of China[NCET-10-0120] ; China Postdoctoral Science Foundation[2012M511883] ; Fundamental Research Funds for the Central Universities[21611203] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000310358400013 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277917]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Gao, Hao |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing, Peoples R China; 2.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China; 3.Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai, Peoples R China; 4.Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China; 5.Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Guo-Dong,Li, Yan-Jun,Gao, Hao,et al. New Azaphilones and Chlorinated Phenolic Glycosides from Chaetomium elatum with Caspase-3 Inhibitory Activity[J]. PLANTA MEDICA,2012,78(15):1683-1689. |
| APA | Chen, Guo-Dong.,Li, Yan-Jun.,Gao, Hao.,Chen, Ying.,Li, Xiao-Xia.,...&Yao, Xin-Sheng.(2012).New Azaphilones and Chlorinated Phenolic Glycosides from Chaetomium elatum with Caspase-3 Inhibitory Activity.PLANTA MEDICA,78(15),1683-1689. |
| MLA | Chen, Guo-Dong,et al."New Azaphilones and Chlorinated Phenolic Glycosides from Chaetomium elatum with Caspase-3 Inhibitory Activity".PLANTA MEDICA 78.15(2012):1683-1689. |
入库方式： OAI收割
来源：上海药物研究所
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