Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades
文献类型：期刊论文
| 作者 | Jiang, Cheng-shi; Liang, Lin-fu; Guo, Yue-wei
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2012-10 |
| 卷号 | 33期号:10页码:1217-1245 |
| 关键词 | natural products phytochemistry protein tyrosine phosphatase 1B (PTP1B) inhibitor structure-activity relationship (SAR) type 2 diabetes obesity |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2012.90 |
| 文献子类 | Review |
| 英文摘要 | This article provides an overview of approximately 300 secondary metabolites with inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), which were isolated from various natural sources or derived from synthetic process in the last decades. The structure-activity relationship and the selectivity of some compounds against other protein phosphatases were also discussed. Potential pharmaceutical applications of several PTP1B inhibitors were presented. |
| WOS关键词 | MANGROVE BRUGUIERA-GYMNORRHIZA ; SPONGE HYRTIOS-ERECTUS ; STEREOSELECTIVE TOTAL-SYNTHESIS ; LICHEN STEREOCAULON-ALPINUM ; FORMAL RADICAL CYCLIZATION ; STEM-BARK ; ACID-DERIVATIVES ; CHEMICAL-CONSTITUENTS ; MACROCYCLIC POLYDISULFIDE ; ISOPRENYLATED FLAVONOIDS |
| 资助项目 | National Marine "863" Project[2011AA09070102] ; Natural Science Foundation of China[31070310] ; Natural Science Foundation of China[40976048] ; Natural Science Foundation of China[21021063] ; Natural Science Foundation of China[21072204] ; Natural Science Foundation of China[81072572] ; SKLDR/SIMM Projects[SIMM1203ZZ-03] ; SKLDR/SIMM Projects[SIMM1105KF-04] ; National S&T Major Projects[2011ZX09307-002-03] ; EU 7th Framework Programme-IRSES Project[00000000] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4639815 |
| WOS记录号 | WOS:000309656500001 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277919]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Guo, Yue-wei |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Cheng-shi,Liang, Lin-fu,Guo, Yue-wei. Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades[J]. ACTA PHARMACOLOGICA SINICA,2012,33(10):1217-1245. |
| APA | Jiang, Cheng-shi,Liang, Lin-fu,&Guo, Yue-wei.(2012).Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades.ACTA PHARMACOLOGICA SINICA,33(10),1217-1245. |
| MLA | Jiang, Cheng-shi,et al."Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades".ACTA PHARMACOLOGICA SINICA 33.10(2012):1217-1245. |
入库方式： OAI收割
来源：上海药物研究所
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