S-52, a novel nootropic compound, protects against beta-amyloid induced neuronal injury by attenuating mitochondrial dysfunction
文献类型：期刊论文
| 作者 | Gao, Xin; Zheng, Chun Yan; Qin, Guo Wei; Tang, Xi Can; Zhang, Hai Yan |
| 刊名 | JOURNAL OF NEUROSCIENCE RESEARCH
 |
| 出版日期 | 2012-10 |
| 卷号 | 90期号:10页码:1981-1988 |
| 关键词 | Alzheimer's disease ss-amyloid reactive oxygen species mitochondrial dysfunction |
| ISSN号 | 0360-4012 |
| DOI | 10.1002/jnr.23086 |
| 文献子类 | Article |
| 英文摘要 | Accumulating evidence suggests that beta-amyloid (A beta)-induced oxidative DNA damage and mitochondrial dysfunction may initiate and contribute to the progression of Alzheimer's disease (AD). This study evaluated the neuroprotective effects of S-52, a novel nootropic compound, on A beta-induced mitochondrial failure. In an established paradigm of moderate cellular injury induced by A beta, S-52 was observed to attenuate the toxicity of A beta to energy metabolism, mitochondrial membrane structure, and key enzymes in the electron transport chain and tricarboxylic acid cycle. In addition, S-52 also effectively inhibited reactive oxygen species accumulation dose dependently not only in A beta-harmed cells but also in unharmed, normal cells. The role of S-52 as a scavenger of free radicals is involved in the antioxidative effect of this compound. The beneficial effects on mitochondria and oxidative stress extend the neuroprotective effects of S-52. The present study provides crucial information for better understanding the beneficial profiles of this compound and discovering novel potential drug candidates for AD therapy. (c) 2012 Wiley Periodicals, Inc. |
| WOS关键词 | ALPHA-KETOGLUTARATE DEHYDROGENASE ; ALZHEIMERS-DISEASE ; A-BETA ; FUNCTIONAL MITOCHONDRIA ; PRECURSOR PROTEIN ; OXIDATIVE STRESS ; FREE-RADICALS ; PC12 CELLS ; METABOLISM ; TOXICITY |
| 资助项目 | Ministry of Science and Technology of China[2011CB510004] ; National Natural Science Foundation of China[81173034] ; National Natural Science Foundation of China[81072646] ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program" of China[2012ZX09301001-001] ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program" of China[2012ZX09301001-004] ; SKLDR/SIMM[SIMM1105KF-04] ; Shanghai Science and Technology Development Funds[10QA1408100] ; SA-SIBS[00000000] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000307383800012 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277937]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Hai Yan |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Xin,Zheng, Chun Yan,Qin, Guo Wei,et al. S-52, a novel nootropic compound, protects against beta-amyloid induced neuronal injury by attenuating mitochondrial dysfunction[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2012,90(10):1981-1988. |
| APA | Gao, Xin,Zheng, Chun Yan,Qin, Guo Wei,Tang, Xi Can,&Zhang, Hai Yan.(2012).S-52, a novel nootropic compound, protects against beta-amyloid induced neuronal injury by attenuating mitochondrial dysfunction.JOURNAL OF NEUROSCIENCE RESEARCH,90(10),1981-1988. |
| MLA | Gao, Xin,et al."S-52, a novel nootropic compound, protects against beta-amyloid induced neuronal injury by attenuating mitochondrial dysfunction".JOURNAL OF NEUROSCIENCE RESEARCH 90.10(2012):1981-1988. |
入库方式： OAI收割
来源：上海药物研究所
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