Potent HGF/c-Met Axis Inhibitors from Eucalyptus globulus: the Coupling of Phloroglucinol and Sesquiterpenoid Is Essential for the Activity
文献类型：期刊论文
| 作者 | Yang, Sheng-Ping2; Zhang, Xiao-Wei2; Ai, Jing2 ; Gan, Li-She1; Xu, Jin-Biao2; Wang, Ying2; Su, Zu-Shang2; Wang, Lu2; Ding, Jian2; Geng, Mei-Yu2
|
| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2012-09-27 |
| 卷号 | 55期号:18页码:8183-8187 |
| ISSN号 | 0022-2623 |
| DOI | 10.1021/jm3007454 |
| 文献子类 | Article |
| 英文摘要 | Eucalyptin A (1), together with two known compounds 2 and 3 exhibiting potent inhibition on HGF/c-Met axis, was discovered from the fruits of Eucalyptus globulus. 1 possessed an unprecedented carbon framework of phloroglucinol-coupled sesquiterpenoid, and its structure was elucidated by spectroscopic method and ECD calculation. A brief structure-activity relationship discussion indicated that the coupling of a phloroglucinol and a sesquiterpenoid is essential for the activity. |
| WOS关键词 | HEPATOCYTE GROWTH-FACTOR ; MACROCARPALS ; METASTASIS ; PRINCIPLES ; ONCOGENE ; GRANDIS ; LABILL |
| 资助项目 | National Natural Science Foundation[81102461] ; National Natural Science Foundation[81021062] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program" of China[2011ZX09307-002-03] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program" of China[2012ZX09301-001-007] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000309153500021 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277941]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 天然药物化学研究室 |
| 通讯作者 | Geng, Mei-Yu |
| 作者单位 | 1.Zhejiang Univ, Coll Pharmaceut Sci, Inst Modern Chinese Med, Hangzhou 310058, Zhejiang, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yang, Sheng-Ping,Zhang, Xiao-Wei,Ai, Jing,et al. Potent HGF/c-Met Axis Inhibitors from Eucalyptus globulus: the Coupling of Phloroglucinol and Sesquiterpenoid Is Essential for the Activity[J]. JOURNAL OF MEDICINAL CHEMISTRY,2012,55(18):8183-8187. |
| APA | Yang, Sheng-Ping.,Zhang, Xiao-Wei.,Ai, Jing.,Gan, Li-She.,Xu, Jin-Biao.,...&Yue, Jian-Min.(2012).Potent HGF/c-Met Axis Inhibitors from Eucalyptus globulus: the Coupling of Phloroglucinol and Sesquiterpenoid Is Essential for the Activity.JOURNAL OF MEDICINAL CHEMISTRY,55(18),8183-8187. |
| MLA | Yang, Sheng-Ping,et al."Potent HGF/c-Met Axis Inhibitors from Eucalyptus globulus: the Coupling of Phloroglucinol and Sesquiterpenoid Is Essential for the Activity".JOURNAL OF MEDICINAL CHEMISTRY 55.18(2012):8183-8187. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。