Newly discovered angiogenesis inhibitors and their mechanisms of action
文献类型：期刊论文
| 作者 | Miao, Ze-hong; Feng, Jian-ming; Ding, Jian
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2012-09 |
| 卷号 | 33期号:9页码:1103-1111 |
| 关键词 | cancer therapy angiogenesis inhibitor antiangiogenic mechanism hypoxia-inducible factor 1 alpha pseudolaric acid B AL3810 |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2012.97 |
| 文献子类 | Review |
| 英文摘要 | In the past decade, the success of angiogenesis inhibitors in clinical contexts has established the antiangiogenic strategy as an important part of cancer therapy. During that time period, we have discovered and reported 17 compounds that exert potent inhibition on angiogenesis. These compounds exhibit tremendous diversity in their sources, structures, targets and mechanisms. These studies have generated new models for further modification and optimization of inhibitory compounds, new information for mechanistic studies and a new drug candidate for clinical development. In particular, through studies on the antiangiogenic mechanism of pseudolaric acid B, we discovered a novel mechanism by which the stability of hypoxia-inducible factor 1 alpha is regulated by the transcription factor c-Jun. We also completed a preclinical study of AL3810, a compound with the potential to circumvent tumor drug resistance to a certain extent. All of these findings will be briefly reviewed in this article. |
| WOS关键词 | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA ; COMBATS TUMOR ANGIOGENESIS ; TYROSINE KINASE INHIBITOR ; PSEUDOLARIC-ACID-B ; IN-VITRO ; ANTITUMOR ; AGENT ; HIF-1-ALPHA ; RESISTANCE ; EXPRESSION |
| 资助项目 | National Natural Science Foundation of China[81025020] ; National Natural Science Foundation of China[81021062] ; National Basic Research Program of China[2012CB932502] ; National Science & Technology Major Project of China[2012ZX09301-001-002] ; Chinese Academy of Sciences[00000000] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4635861 |
| WOS记录号 | WOS:000308391000002 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277958]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Miao, Ze-hong |
| 作者单位 | Chinese Acad Sci, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Miao, Ze-hong,Feng, Jian-ming,Ding, Jian. Newly discovered angiogenesis inhibitors and their mechanisms of action[J]. ACTA PHARMACOLOGICA SINICA,2012,33(9):1103-1111. |
| APA | Miao, Ze-hong,Feng, Jian-ming,&Ding, Jian.(2012).Newly discovered angiogenesis inhibitors and their mechanisms of action.ACTA PHARMACOLOGICA SINICA,33(9),1103-1111. |
| MLA | Miao, Ze-hong,et al."Newly discovered angiogenesis inhibitors and their mechanisms of action".ACTA PHARMACOLOGICA SINICA 33.9(2012):1103-1111. |
入库方式： OAI收割
来源：上海药物研究所
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