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Immunosuppressant discovery from Tripterygium wilfordii Hook f: the novel triptolide analog (5R)-5-hydroxytriptolide (LLDT-8)
文献类型：期刊论文
| 作者 | Tang, Wei ; Zuo, Jian-ping
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2012-09 |
| 卷号 | 33期号:9页码:1112-1118 |
| 关键词 | Tripterygium wilfordii Hook f triptolide (5R)-5-hydroxytriptolide (LLDT-8) autoimmune diseases immunosuppressants clinical trials |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2012.108 |
| 文献子类 | Review |
| 英文摘要 | The Chinese traditional herb Tripterygium wilfordii Hook f (TwHF) has been widely used in the treatment of autoimmune and inflammatory diseases. Over the past few decades, great efforts have been made to explore modern preparations of TwHF with higher efficacy, solubility, and lower toxicity. In this study, we reviewed several examples both of naturally occurring compounds and their derivatives in TwHF, and summarized the preclinical evaluations with regard to autoimmune and inflammatory diseases. All of the candidate compounds described herein have been or are currently in clinical trials. Although some studies encountered problems, the data still provided valuable references for future studies. (5R)-5-hydroxytriptolide (LLDT-8, Leitengshu) is a novel triptolide derivative with potent immunosuppressive and anti-inflammatory activities developed at Shanghai Institute of Materia Medica. Indeed, a Phase I clinical trial for this compound has been completed in rheumatoid arthritis patients. The results will provide the basis for the further exploration of this ancient herb and encourage the research and development of valuable traditional Chinese medicine. |
| WOS关键词 | COLLAGEN-INDUCED ARTHRITIS ; VERSUS-HOST-DISEASE ; BONE-MARROW TRANSPLANTATION ; INTERFERON-GAMMA PRODUCTION ; RENAL-ALLOGRAFT SURVIVAL ; CHINESE HERBAL REMEDY ; INDUCED LUNG FIBROSIS ; NATURAL-PRODUCTS ; RHEUMATOID-ARTHRITIS ; DRUG DISCOVERY |
| 资助项目 | National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program" of China[2012ZX09102-101-006] ; Science and Technology Commission of Shanghai Municipality (STCSM)[08XD14053] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4635862 |
| WOS记录号 | WOS:000308391000003 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277959]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zuo, Jian-ping |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Lab Immunopharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Wei,Zuo, Jian-ping. Immunosuppressant discovery from Tripterygium wilfordii Hook f: the novel triptolide analog (5R)-5-hydroxytriptolide (LLDT-8)[J]. ACTA PHARMACOLOGICA SINICA,2012,33(9):1112-1118. |
| APA | Tang, Wei,&Zuo, Jian-ping.(2012).Immunosuppressant discovery from Tripterygium wilfordii Hook f: the novel triptolide analog (5R)-5-hydroxytriptolide (LLDT-8).ACTA PHARMACOLOGICA SINICA,33(9),1112-1118. |
| MLA | Tang, Wei,et al."Immunosuppressant discovery from Tripterygium wilfordii Hook f: the novel triptolide analog (5R)-5-hydroxytriptolide (LLDT-8)".ACTA PHARMACOLOGICA SINICA 33.9(2012):1112-1118. |
入库方式： OAI收割
来源：上海药物研究所
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