Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components
文献类型：期刊论文
| 作者 | Wu, Wen-yu; Wang, Yi-ping
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2012-09 |
| 卷号 | 33期号:9页码:1119-1130 |
| 关键词 | traditional Chinese medicine Salvia miltiorrhiza depside salt magnesium lithospermate B (lithospermic acid B or salvianolic acid B) rosmarinic acid lithospermic acid cardiovascular activities |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2012.126 |
| 文献子类 | Review |
| 英文摘要 | Salvia miltiorrhiza, a traditional medical herb known as danshen, has been widely used in China to improve blood circulation, relieve blood stasis, and treat coronary heart disease. S miltiorrhiza depside salt is a novel drug recently developed at the Shanghai Institute of Materia Medica; it contains magnesium lithospermate B (MLB) and its analogs, rosmarinic acid (RA) and lithospermic acid (LA), as active components. The drug has been used in the clinic to improve blood circulation and treat coronary heart disease. The pharmacological effects of the depside salt from S miltiorrhiza and its components have been extensively investigated. Experimental studies have demonstrated that magnesium lithospermate B possesses a variety of biological activities, especially protective effects in the cardiovascular system such as attenuation of atherosclerosis and protection against myocardial ischemia-reperfusion injury. Rosmarinic acid and lithospermic acid also show beneficial effects on the cardiovascular system. This paper reviews the recent findings regarding the mechanisms underlying the pharmacological actions of the active components of S miltiorrhiza depside salt, based on published works and our own observations. |
| WOS关键词 | MAGNESIUM-LITHOSPERMATE-B ; SMOOTH-MUSCLE-CELLS ; HEPATIC STELLATE CELLS ; NECROSIS-FACTOR-ALPHA ; TO-MESENCHYMAL TRANSITION ; AORTIC ENDOTHELIAL-CELLS ; DEFICIENT MOUSE AORTA ; ACID-B ; ROSMARINIC ACID ; IN-VITRO |
| 资助项目 | Shanghai Committee of Science and Technology, China[09DZ1977402] ; Ministry of Science and Technology of China[2010ZX09502-003] ; Ministry of Science and Technology of China[2003AA2Z3269] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4635863 |
| WOS记录号 | WOS:000308391000004 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277960]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Yi-ping |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Wen-yu,Wang, Yi-ping. Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components[J]. ACTA PHARMACOLOGICA SINICA,2012,33(9):1119-1130. |
| APA | Wu, Wen-yu,&Wang, Yi-ping.(2012).Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components.ACTA PHARMACOLOGICA SINICA,33(9),1119-1130. |
| MLA | Wu, Wen-yu,et al."Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components".ACTA PHARMACOLOGICA SINICA 33.9(2012):1119-1130. |
入库方式： OAI收割
来源：上海药物研究所
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