Discovery of structurally diverse and bioactive compounds from plant resources in China
文献类型：期刊论文
| 作者 | Yang, Sheng-ping; Yue, Jian-min
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2012-09 |
| 卷号 | 33期号:9页码:1147-1158 |
| 关键词 | natural products plant resources traditional Chinese medicine bioactive compounds structural modification structure-activity relationship |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2012.105 |
| 文献子类 | Review |
| 英文摘要 | This review describes the major discoveries of structurally diverse and/or biologically significant compounds from plant resources in China, mainly from the traditional Chinese medicines (TCMs) since the establishment of our research group in 1999. In the past decade, a large array of biologically significant and novel structures has been identified from plant resources (or TCM) in our laboratory. The structural modification of several biologically important compounds led to more than 400 derivatives, some of which exhibited significantly improved activities and provided opportunities to elucidate the structure-activity relationship of the related compound class. These findings are important for drug discovery and help us understand the biological basis for the traditional applications of these plants in TCM. |
| WOS关键词 | MANGROVE XYLOCARPUS-GRANATUM ; SONOCHEMICAL BLAISE REACTION ; POTASSIUM CHANNEL BLOCKERS ; DAPHNANE-TYPE DITERPENOIDS ; B INHIBITS ANGIOGENESIS ; PSEUDOLARIX ACID-B ; CHUKRASIA-TABULARIS ; A-E ; TURRAEA-PUBESCENS ; INDOLE ALKALOIDS |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2011ZX09307-002-03] ; foundation of the Ministry of Science and Technology of China[2012CB721105] ; National Natural Science Foundation of China[30025044] ; National Natural Science Foundation of China[30630072] ; National Natural Science Foundation of China[21072203] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4635866 |
| WOS记录号 | WOS:000308391000007 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277963]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-min |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Sheng-ping,Yue, Jian-min. Discovery of structurally diverse and bioactive compounds from plant resources in China[J]. ACTA PHARMACOLOGICA SINICA,2012,33(9):1147-1158. |
| APA | Yang, Sheng-ping,&Yue, Jian-min.(2012).Discovery of structurally diverse and bioactive compounds from plant resources in China.ACTA PHARMACOLOGICA SINICA,33(9),1147-1158. |
| MLA | Yang, Sheng-ping,et al."Discovery of structurally diverse and bioactive compounds from plant resources in China".ACTA PHARMACOLOGICA SINICA 33.9(2012):1147-1158. |
入库方式： OAI收割
来源：上海药物研究所
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