New insights into huperzine A for the treatment of Alzheimer's disease
文献类型：期刊论文
| 作者 | Zhang, Hai-yan
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2012-09 |
| 卷号 | 33期号:9页码:1170-1175 |
| 关键词 | Alzheimer's disease huperzine A acetylcholinesterase mitochondrion controlled release |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2012.128 |
| 文献子类 | Article |
| 英文摘要 | Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). Accordingly, some new mechanisms of action for huperzine A have been discovered over the past decades. In addition to its AChE inhibitory effect, potent multifaceted neuroprotective effect through activating cholinergic system and directly acting on mitochondria have been explored. Moreover, in order to maximize the efficacy and safety of huperzine A therapy, great efforts have been made to optimize drug delivery system. In the present article, an attempt is made to discuss the current progress and future perspective for huperzine A therapy in AD. |
| WOS关键词 | NERVE GROWTH-FACTOR ; AMYLOID PRECURSOR PROTEIN ; RAT CORTICAL-NEURONS ; ATTENUATES MITOCHONDRIAL DYSFUNCTION ; NICOTINIC ACETYLCHOLINE-RECEPTOR ; INDUCED OXIDATIVE INJURY ; A LOADED MICROSPHERES ; PC12 CELLS ; CEREBRAL-ISCHEMIA ; BETA-PEPTIDE |
| 资助项目 | Ministry of Science and Technology of China[2011CB510004] ; National Natural Science Foundation of China[81173034] ; National Natural Science Foundation of China[81072646] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program" of China[2012ZX09301001001] ; SKLDR/SIMM Projects[SIM-M1105KF-04] ; Shanghai Science and Technology Development Funds, SA-SIBS Scholarship Program[10QA1408100] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4635868 |
| WOS记录号 | WOS:000308391000009 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277965]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Hai-yan |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Hai-yan. New insights into huperzine A for the treatment of Alzheimer's disease[J]. ACTA PHARMACOLOGICA SINICA,2012,33(9):1170-1175. |
| APA | Zhang, Hai-yan.(2012).New insights into huperzine A for the treatment of Alzheimer's disease.ACTA PHARMACOLOGICA SINICA,33(9),1170-1175. |
| MLA | Zhang, Hai-yan."New insights into huperzine A for the treatment of Alzheimer's disease".ACTA PHARMACOLOGICA SINICA 33.9(2012):1170-1175. |
入库方式： OAI收割
来源：上海药物研究所
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