Recent Advances in Neuraminidase Inhibitor Development as Anti-influenza Drugs
文献类型：期刊论文
| 作者 | Feng, Enguang2; Ye, Deju2; Li, Jian2; Zhang, Dengyou2; Wang, Jinfang2; Zhao, Fei2; Hilgenfeld, Rolf1,2; Zheng, Mingyue2 ; Jiang, Hualiang2; Liu, Hong2
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| 刊名 | CHEMMEDCHEM
 |
| 出版日期 | 2012-09 |
| 卷号 | 7期号:9页码:1527-1536 |
| 关键词 | antiviral agents drug design influenza inhibitors neuraminidase |
| ISSN号 | 1860-7179 |
| DOI | 10.1002/cmdc.201200155 |
| 文献子类 | Review |
| 英文摘要 | The recent emergence of the highly pathogenic H5N1 subtype of avian influenza virus (AIV) and of the new type of human influenza A (H1N1) have emphasized the need for the development of effective anti-influenza drugs. Presently, neuraminidase (NA) inhibitors are widely used in the treatment and prophylaxis of human influenza virus infection, and tremendous efforts have been made to develop more potent NA inhibitors to combat resistance and new influenza viruses. In this review, we discuss the structural characteristics of NA catalytic domains and the recent developments of new NA inhibitors using structure-based drug design strategies. These drugs include analogues of zanamivir, analogues of oseltamivir, analogues of peramivir, and analogues of aromatic carboxylic acid and present promising options for therapeutics or leads for further development of NA inhibitors that may be useful in the event of a future influenza pandemic. |
| WOS关键词 | INFLUENZA-VIRUS NEURAMINIDASE ; OSELTAMIVIR-RESISTANT INFLUENZA ; H5N1 AVIAN INFLUENZA ; BEARING 4-GUANIDINO-NEU5AC2EN DERIVATIVES ; STRUCTURE-BASED DESIGN ; SIALIC-ACID ; ANTIGENIC DRIFT ; HIGHLY POTENT ; ACTIVE-SITE ; ZANAMIVIR |
| 资助项目 | National Basic Research Program of China[2009CB940903] ; National Basic Research Program of China[2012CB518000] ; National Natural Science Foundation of China[20721003] ; National Natural Science Foundation of China[81025017] ; National S&T Major Projects[2012ZX09103-101-072] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000308042000001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277972]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | 1.Med Univ Lubeck, Inst Biochem, Ctr Struct & Cell Biol Med, D-23538 Lubeck, Germany 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Grad Sch,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Feng, Enguang,Ye, Deju,Li, Jian,et al. Recent Advances in Neuraminidase Inhibitor Development as Anti-influenza Drugs[J]. CHEMMEDCHEM,2012,7(9):1527-1536. |
| APA | Feng, Enguang.,Ye, Deju.,Li, Jian.,Zhang, Dengyou.,Wang, Jinfang.,...&Liu, Hong.(2012).Recent Advances in Neuraminidase Inhibitor Development as Anti-influenza Drugs.CHEMMEDCHEM,7(9),1527-1536. |
| MLA | Feng, Enguang,et al."Recent Advances in Neuraminidase Inhibitor Development as Anti-influenza Drugs".CHEMMEDCHEM 7.9(2012):1527-1536. |
入库方式： OAI收割
来源：上海药物研究所
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