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The Antiepileptic Drug Valproic Acid Restores T Cell Homeostasis and Ameliorates Pathogenesis of Experimental Autoimmune Encephalomyelitis

文献类型：期刊论文

作者Lv, Jie3; Du, Changsheng3; Wei, Wei1,3; Wu, Zhiying2,4; Zhao, Guixian2,4; Li, Zhenxin2,4; Xie, Xin1,3
刊名JOURNAL OF BIOLOGICAL CHEMISTRY
出版日期2012-08-17
卷号287期号:34页码:28656-28665
ISSN号0021-9258
DOI10.1074/jbc.M112.356584
文献子类Article
英文摘要Maintaining a constant number and ratio of immune cells is one critical aspect of the tight regulation of immune homeostasis. Breakdown of this balance will lead to autoimmune diseases such as multiple sclerosis (MS). The antiepileptic drug valproic acid (VPA) was reported to regulate the growth, survival, and differentiation of many cells. However, its function in T cell homeostasis and MS treatment remains unknown. In this study, VPA was found to reduce spinal cord inflammation, demyelination, and disease scores in experimental autoimmune encephalomyelitis, a mouse model of MS. Further study indicated that VPA induces apoptosis in activated T cells and maintains the immune homeostasis. This effect was found to be mainly mediated by the caspase-8/caspase-3 pathway. Interestingly, this phenomenon was also confirmed in T cells from normal human subjects and MS patients. Considering the long history of clinical use and our new findings, we believe VPA might be a safe and effective therapy for autoimmune diseases, such as multiple sclerosis.
WOS关键词HISTONE DEACETYLASE INHIBITORS ; MULTIPLE-SCLEROSIS ; IMMUNE HOMEOSTASIS ; TRICHOSTATIN-A ; TGF-BETA ; APOPTOSIS ; THERAPY ; SYSTEM ; BCL-2 ; HDAC
资助项目National Natural Science Foundation of China[31000399] ; National Natural Science Foundation of China[31171348] ; National Natural Science Foundation of China[31071227] ; National Natural Science Foundation of China[81100963] ; 973 Program[2012CB910404] ; Ministry of Science and Technology of China[2009ZX09302-001]
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:000308074600039
出版者AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
源URL[http://119.78.100.183/handle/2S10ELR8/277985]  
专题国家新药筛选中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Xie, Xin
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.Fudan Univ, Shanghai Med Coll, Huashan Hosp, Inst Neurol, Shanghai 200040, Peoples R China
3.Tongji Univ, Shanghai Key Lab Signaling & Dis Res, Lab Receptor Based Biomed, Sch Life Sci & Technol, Shanghai 200092, Peoples R China;
4.Fudan Univ, Shanghai Med Coll, Huashan Hosp, Dept Neurol, Shanghai 200040, Peoples R China;
推荐引用方式
GB/T 7714		 Lv, Jie,Du, Changsheng,Wei, Wei,et al. The Antiepileptic Drug Valproic Acid Restores T Cell Homeostasis and Ameliorates Pathogenesis of Experimental Autoimmune Encephalomyelitis[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2012,287(34):28656-28665.
APA Lv, Jie.,Du, Changsheng.,Wei, Wei.,Wu, Zhiying.,Zhao, Guixian.,...&Xie, Xin.(2012).The Antiepileptic Drug Valproic Acid Restores T Cell Homeostasis and Ameliorates Pathogenesis of Experimental Autoimmune Encephalomyelitis.JOURNAL OF BIOLOGICAL CHEMISTRY,287(34),28656-28665.
MLA Lv, Jie,et al."The Antiepileptic Drug Valproic Acid Restores T Cell Homeostasis and Ameliorates Pathogenesis of Experimental Autoimmune Encephalomyelitis".JOURNAL OF BIOLOGICAL CHEMISTRY 287.34(2012):28656-28665.

入库方式： OAI收割

来源：上海药物研究所

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