Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism
文献类型：期刊论文
| 作者 | Gu, Yuan3; Qi, Chunting3; Sun, Xiaoxiao3; Ma, Xiuquan1; Zhang, Haohao3; Hu, Lihong4; Yuan, Junying2; Yu, Qiang3
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| 刊名 | BIOCHEMICAL PHARMACOLOGY
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| 出版日期 | 2012-08-15 |
| 卷号 | 84期号:4页码:468-476 |
| 关键词 | Arctigenin Glucose deprivation Tumor cell death ATP levels ROS generation |
| ISSN号 | 0006-2952 |
| DOI | 10.1016/j.bcp.2012.06.002 |
| 文献子类 | Article |
| 英文摘要 | Selectively eradicating cancer cells with minimum adverse effects on normal cells is a major challenge in the development of anticancer therapy. We hypothesize that nutrient-limiting conditions frequently encountered by cancer cells in poorly vascularized solid tumors might provide an opportunity for developing selective therapy. In this study, we investigated the function and molecular mechanisms of a natural compound, arctigenin, in regulating tumor cell growth. We demonstrated that arctigenin selectively promoted glucose-starved A549 tumor cells to undergo necrosis by inhibiting mitochondrial respiration. In doing so, arctigenin elevated cellular level of reactive oxygen species (ROS) and blocked cellular energy metabolism in the glucose-starved tumor cells. We also demonstrated that cellular ROS generation was caused by intracellular ATP depletion and played an essential role in the arctigenin-induced tumor cell death under the glucose-limiting condition. Furthermore, we combined arctigenin with the glucose analogue 2-deoxyglucose (2DG) and examined their effects on tumor cell growth. Interestingly, this combination displayed preferential cell-death inducing activity against tumor cells compared to normal cells. Hence, we propose that the combination of arctigenin and 2DG may represent a promising new cancer therapy with minimal normal tissue toxicity. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved. |
| WOS关键词 | ACTIVATED PROTEIN-KINASE ; RESPIRATORY COMPLEX-I ; CANCER-CELLS ; NUTRIENT STARVATION ; ADENINE-NUCLEOTIDES ; ANTITUMOR-ACTIVITY ; METFORMIN EXERTS ; BERBERINE ; TOLERANCE ; CYTOTOXICITY |
| 资助项目 | China National Natural Science Foundation[31129004] ; China National Natural Science Foundation[31000619] ; China National Natural Science Foundation[30925040] ; China National Natural Science Foundation[81102329] ; China National Natural Science Foundation[91129701] ; National Science & Technology Key Project[2012CB910704] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000307135600008 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277986]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yu, Qiang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Organ Chem, Dept Bioorgan Chem, Shanghai 200032, Peoples R China; 2.Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA USA 3.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Tumor Pharmacol, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Gu, Yuan,Qi, Chunting,Sun, Xiaoxiao,et al. Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism[J]. BIOCHEMICAL PHARMACOLOGY,2012,84(4):468-476. |
| APA | Gu, Yuan.,Qi, Chunting.,Sun, Xiaoxiao.,Ma, Xiuquan.,Zhang, Haohao.,...&Yu, Qiang.(2012).Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism.BIOCHEMICAL PHARMACOLOGY,84(4),468-476. |
| MLA | Gu, Yuan,et al."Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism".BIOCHEMICAL PHARMACOLOGY 84.4(2012):468-476. |
入库方式： OAI收割
来源：上海药物研究所
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