Highly Enantioselective Michael Addition of 2-Oxindole-3-carboxylate Esters to Nitroolefins Promoted by Cinchona Alkaloid-Thiourea-Bronsted Acid Cocatalysts
文献类型：期刊论文
| 作者 | Chen, Xianjie1,2,3; Zhu, Wei1; Qian, Wangke1; Feng, Enguang1; Zhou, Yu1 ; Wang, Jinfang1; Jiang, Hualiang1,2,3; Yao, Zhu-Jun2,3; Liu, Hong1
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| 刊名 | ADVANCED SYNTHESIS & CATALYSIS
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| 出版日期 | 2012-08 |
| 卷号 | 354期号:11-12页码:2151-2156 |
| 关键词 | nitroolefins 2-oxindole-3-carboxylate esters spirooxindoles thiourea-Bronsted cocatalysis |
| ISSN号 | 1615-4150 |
| DOI | 10.1002/adsc.201200206 |
| 文献子类 | Article |
| 英文摘要 | A highly efficient organocatalyzed Michael addition of 2-oxindole-3-carboxylate esters to nitroolefins using a Cinchona alkaloid-thiourea and an achiral Bronsted acid as cooperative organocatalysts is reproted that affords significantly improved enantioselectivity and diastereoselectivity. It also provides an efficient approach to the synthesis of spirooxindole derivatives with high enantioselectivity. |
| WOS关键词 | PICTET-SPENGLER REACTIONS ; ASYMMETRIC MICHAEL ; CONJUGATE ADDITION ; 3,3'-DISUBSTITUTED OXINDOLES ; QUATERNARY STEREOCENTERS ; 1,3-DICARBONYL COMPOUNDS ; 3-SUBSTITUTED OXINDOLES ; SPIROCYCLIC OXINDOLES ; CONCISE SYNTHESIS ; CONSTRUCTION |
| 资助项目 | National Basic Research Program of China[2009CB940903] ; National Basic Research Program of China[2012CB518000] ; National Natural Science Foundation of China[20721003] ; National Natural Science Foundation of China[81025017] ; National S&T Major Projects[2012ZX09103-101-072] ; Silver Project[260644] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000307376400016 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277989]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物发现与设计中心 药理学第一研究室 |
| 通讯作者 | Yao, Zhu-Jun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 2.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China; 3.Nanjing Univ, Nanjing Natl Lab Microstruct, Nanjing 210093, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Chen, Xianjie,Zhu, Wei,Qian, Wangke,et al. Highly Enantioselective Michael Addition of 2-Oxindole-3-carboxylate Esters to Nitroolefins Promoted by Cinchona Alkaloid-Thiourea-Bronsted Acid Cocatalysts[J]. ADVANCED SYNTHESIS & CATALYSIS,2012,354(11-12):2151-2156. |
| APA | Chen, Xianjie.,Zhu, Wei.,Qian, Wangke.,Feng, Enguang.,Zhou, Yu.,...&Liu, Hong.(2012).Highly Enantioselective Michael Addition of 2-Oxindole-3-carboxylate Esters to Nitroolefins Promoted by Cinchona Alkaloid-Thiourea-Bronsted Acid Cocatalysts.ADVANCED SYNTHESIS & CATALYSIS,354(11-12),2151-2156. |
| MLA | Chen, Xianjie,et al."Highly Enantioselective Michael Addition of 2-Oxindole-3-carboxylate Esters to Nitroolefins Promoted by Cinchona Alkaloid-Thiourea-Bronsted Acid Cocatalysts".ADVANCED SYNTHESIS & CATALYSIS 354.11-12(2012):2151-2156. |
入库方式： OAI收割
来源：上海药物研究所
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