Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors
文献类型：期刊论文
| 作者 | Zheng, Yong-Yong2; Guo, Lin1; Zhen, Xue-Chu1; Li, Jian-Qi2 |
| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2012-08 |
| 卷号 | 54页码:123-136 |
| 关键词 | Arylalkanol-piperidine derivatives Triple reuptake inhibitor Antidepressant |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2012.04.030 |
| 文献子类 | Article |
| 英文摘要 | A series of arylalkanol-piperidine derivatives was synthesized, and their triple reuptake inhibition and in vivo activities have been evaluated. Among them, compounds 2a, 2j, 2k, 2m and 2n exhibited high potency for 5-HT, NA and DA transporters. Optimized compounds 2j and 2m showed significant reduction of immobility time compared to that of vehicle in the mouse tail suspension test (TST) test at doses ranging from 10 to 50 mg/kg po, and were not generally motor stimulants at 50 mg/kg dose. In addition, compounds 2j and 2m displayed desirable pharmacokinetic properties in SD rats. (C) 2012 Elsevier Masson SAS. All rights reserved. |
| WOS关键词 | DEPRESSION ; AGENTS ; TRANSPORTERS ; POTENT |
| 资助项目 | National Natural Science Foundation of China[30772623] ; Chinese National Science and Technology Major Project[2012ZX09103-101-038] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000307920600014 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277993]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Li, Jian-Qi |
| 作者单位 | 1.Chinese Acad Sci, SIMM, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Shanghai Inst Pharmaceut Ind, Novel Technol Ctr Pharmaceut Chem, Shanghai 200437, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zheng, Yong-Yong,Guo, Lin,Zhen, Xue-Chu,et al. Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2012,54:123-136. |
| APA | Zheng, Yong-Yong,Guo, Lin,Zhen, Xue-Chu,&Li, Jian-Qi.(2012).Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,54,123-136. |
| MLA | Zheng, Yong-Yong,et al."Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 54(2012):123-136. |
入库方式： OAI收割
来源：上海药物研究所
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