Morusalbanol A, a neuro-protective Diels-Alder adduct with an unprecedented architecture from Morus alba
文献类型：期刊论文
| 作者 | Chen, Hua-Dong1; Ding, Yuan-Qing2,3; Yang, Sheng-Ping1; Li, Xing-Cong2,3; Wang, Xu-Jie1; Zhang, Hai-Yan1 ; Ferreira, Daneel2,3; Yue, Jian-Min1
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| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2012-07-29 |
| 卷号 | 68期号:30页码:6054-6058 |
| 关键词 | Morus alba Natural products Morusalbanol A Absolute configuration Neuro-protective activity |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2012.05.017 |
| 文献子类 | Article |
| 英文摘要 | Morusalbanol A (1), a neuro-protective Diels Alder adduct with a new carbon skeleton, was isolated from the bark of Morus alba. Compound 1 showed evidence of interesting astropisomerism, and resulted in the absence of a number of key proton and carbon signals in the NMR spectra. Its structure was thus elucidated by spectroscopic analysis of its peracetylated derivative (2) and its absolute configuration established as 1S,3S,4R,55 via experimental and calculated ECD spectra of 1. In a neuro-protective assay, morusalbanol A (1) significantly attenuated the H2O2-induced cell damage in a dose-dependent manner. (C) 2012 Elsevier Ltd. All rights reserved. |
| WOS关键词 | ELECTRONIC CIRCULAR-DICHROISM ; THEORETICAL CALCULATION ; MORACEOUS PLANTS ; FLAVONOIDS ; BIOSYNTHESIS ; CHEMISTRY |
| 资助项目 | National Natural Science Foundation of the People's Republic of China[81021062] ; National Natural Science Foundation of the People's Republic of China[20932007] ; USDA Agricultural Research Service[58-6408-2-0009] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000306042000011 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278010]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA 3.Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA; |
| 推荐引用方式 GB/T 7714 | Chen, Hua-Dong,Ding, Yuan-Qing,Yang, Sheng-Ping,et al. Morusalbanol A, a neuro-protective Diels-Alder adduct with an unprecedented architecture from Morus alba[J]. TETRAHEDRON,2012,68(30):6054-6058. |
| APA | Chen, Hua-Dong.,Ding, Yuan-Qing.,Yang, Sheng-Ping.,Li, Xing-Cong.,Wang, Xu-Jie.,...&Yue, Jian-Min.(2012).Morusalbanol A, a neuro-protective Diels-Alder adduct with an unprecedented architecture from Morus alba.TETRAHEDRON,68(30),6054-6058. |
| MLA | Chen, Hua-Dong,et al."Morusalbanol A, a neuro-protective Diels-Alder adduct with an unprecedented architecture from Morus alba".TETRAHEDRON 68.30(2012):6054-6058. |
入库方式： OAI收割
来源：上海药物研究所
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