Copper-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Amine and alpha-Carbonyl Aldehyde: A Practical and Efficient Approach to alpha-Ketoamides with Wide Substrate Scope
文献类型：期刊论文
| 作者 | Zhang, Chun2; Zong, Xiaolin2; Zhang, Liangren2; Jiao, Ning1 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2012-07-06 |
| 卷号 | 14期号:13页码:3280-3283 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol301130u |
| 文献子类 | Article |
| 英文摘要 | A copper-catalyzed aerobic oxidative cross-dehydrogenative coupling (CDC) of amine with alpha-carbonyl aldehyde has been developed. Many types of amines are tolerant in this transformation leading to various alpha-ketoamides compounds. Wide substrate scope, CDC strategy and using air as oxidant make this transformation highly efficient and practical. Molecular oxygen acts not only as the oxidant, but also as an initiator to trigger this catalytic process. Furthermore, mechanism studies show that carbonyl group of a-carbonyl aldehyde plays a role as the directing group to facilitate this chemical process. |
| WOS关键词 | O-O BOND ; MOLECULAR-OXYGEN ; OXIDASE CATALYSIS ; ROOM-TEMPERATURE ; DIRECT ACCESS ; KETO-AMIDES ; PALLADIUM ; AMIDATION ; COMPLEXES ; DIOXYGEN |
| 资助项目 | National Basic Research Program of China (973 Program)[2009CB825300] ; National Science Foundation of China[20872003] ; State Key Laboratory of Drug Research[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000306050300012 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278019]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Jiao, Ning |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Chun,Zong, Xiaolin,Zhang, Liangren,et al. Copper-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Amine and alpha-Carbonyl Aldehyde: A Practical and Efficient Approach to alpha-Ketoamides with Wide Substrate Scope[J]. ORGANIC LETTERS,2012,14(13):3280-3283. |
| APA | Zhang, Chun,Zong, Xiaolin,Zhang, Liangren,&Jiao, Ning.(2012).Copper-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Amine and alpha-Carbonyl Aldehyde: A Practical and Efficient Approach to alpha-Ketoamides with Wide Substrate Scope.ORGANIC LETTERS,14(13),3280-3283. |
| MLA | Zhang, Chun,et al."Copper-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Amine and alpha-Carbonyl Aldehyde: A Practical and Efficient Approach to alpha-Ketoamides with Wide Substrate Scope".ORGANIC LETTERS 14.13(2012):3280-3283. |
入库方式： OAI收割
来源：上海药物研究所
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